Identification and Characterization of a Phospholipase C Activity in Resident Mouse Peritoneal Macrophages. Inhibition of the Enzyme by Phenothiazines

Overview

Journal Biochem J

Specialty Biochemistry

Date 1981 Aug 1

PMID 7325971

Citations 11

Authors

P D Wightman

M E Dahlgren

J C Hall

P Davies

R J Bonney

Affiliations

Soon will be listed here.

Abstract

Resident mouse peritoneal macrophages contain a phospholipase C of high activity that is specific for phosphatidylinositol. The activity has a neutral pH optimum, is Ca(2+)-dependent and has a maximum reaction velocity of 525nmol/h per mg of protein. Certain phenothiazines are potent inhibitors of this activity.

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