Glucose Turnover During Pregnancy in Anaesthetized Post-absorptive Rats

Overview

Journal Biochem J

Specialty Biochemistry

Date 1981 May 15

PMID 7317001

Citations 6

Authors

A Leturque

M Gilbert

J Girard

Affiliations

Soon will be listed here.

Abstract

During pregnancy the decline in blood [glucose] does not result from the increased distribution space of glucose. The absolute rate of glucose turnover increases in late pregnancy in parallel with the rise in the mass of the conceptus. Nevertheless, glucose turnover per kg body wt. is not increased in late pregnancy, since the lower blood [glucose] decreases glucose utilization by maternal tissues.

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References

Herrera E, Knopp R, Freinkel N . Carbohydrate metabolism in pregnancy. VI. Plasma fuels, insulin, liver composition, gluconeogenesis, and nitrogen metabolism during late gestation in the fed and fasted rat. J Clin Invest. 1969; 48(12):2260-72. PMC: 297483. DOI: 10.1172/JCI106192. View

Bleicher S, OSullivan J, Freinkel N . CARBOHYDRATE METABOLISM IN PREGNANCY. V. THE INTERRELATIONS OF GLUCOSE, INSULIN AND FREE FATTY ACIDS IN LATE PREGNANCY AND POST PARTUM. N Engl J Med. 1964; 271:866-72. DOI: 10.1056/NEJM196410222711702. View

Girard J, Cuendet G, Marliss E, Kervran A, Rieutort M, Assan R . Fuels, hormones, and liver metabolism at term and during the early postnatal period in the rat. J Clin Invest. 1973; 52(12):3190-200. PMC: 302595. DOI: 10.1172/JCI107519. View

Victor A . Normal blood sugar variation during pregnancy. Acta Obstet Gynecol Scand. 1974; 53(1):37-40. DOI: 10.3109/00016347409156886. View

Bergman E, Brockman R, Kaufman C . Glucose metabolism in ruminants: comparison of whole-body turnover with production by gut, liver, and kidneys. Fed Proc. 1974; 33(7):1849-54. View

FELIG P . Maternal and fetal fuel homeostasis in human pregnancy. Am J Clin Nutr. 1973; 26(9):998-1005. DOI: 10.1093/ajcn/26.9.998. View

Knopp R, Boroush M, OSullivan J . Lipid metabolism in pregnancy. II. Postheparin lipolytic acitivity and hypertriglyceridemia in the pregnant rat. Metabolism. 1975; 24(4):481-93. DOI: 10.1016/0026-0495(75)90073-6. View

Katz J, Golden S, Dunn A, Chenoweth M . Estimation of glucose turnover in rats in vivo with tritium labeled glucoses. Hoppe Seylers Z Physiol Chem. 1976; 357(10):1387-94. DOI: 10.1515/bchm2.1976.357.2.1387. View

Cherrington A, Williams P, Harris M . Relationship between the plasma glucose level and glucose uptake in the conscious dog. Metabolism. 1978; 27(7):787-91. DOI: 10.1016/0026-0495(78)90213-5. View

10.

Kalhan S, DAngelo L, Savin S, Adam P . Glucose production in pregnant women at term gestation. Sources of glucose for human fetus. J Clin Invest. 1979; 63(3):388-94. PMC: 371965. DOI: 10.1172/JCI109314. View

11.

Meschia G, Battaglia F, Hay W, Sparks J . Utilization of substrates by the ovine placenta in vivo. Fed Proc. 1980; 39(2):245-9. View

12.

Cousins L, Rigg L, Hollingsworth D, Brink G, Aurand J, Yen S . The 24-hour excursion and diurnal rhythm of glucose, insulin, and C-peptide in normal pregnancy. Am J Obstet Gynecol. 1980; 136(4):483-8. DOI: 10.1016/0002-9378(80)90675-4. View

13.

. Abstracts: annual meeting--1979 Midwest Society for Pediatric Research, October 30 and 31, Cincinnati. J Pediatr. 1980; 96(6):1105-19. View

14.

SILVERSTONE F, SOLOMONS E, RUBRICIUS J . The rapid intravenous glucose tolerance test in pregnancy. J Clin Invest. 1961; 40:2180-9. PMC: 290927. DOI: 10.1172/JCI104444. View

15.

FELL B, Smith K, Campbell R . Hypertrophic and hyperplastic changes in the alimentary canal of the lactating rat. J Pathol Bacteriol. 1963; 85:179-88. DOI: 10.1002/path.1700850117. View

16.

Bergman E . Quantitative aspects of glucose metabolism in pregnant and nonpregnant sheep. Am J Physiol. 1963; 204:147-52. DOI: 10.1152/ajplegacy.1963.204.1.147. View

17.

SCOW R, CHERNICK S, BRINLEY M . HYPERLIPEMIA AND KETOSIS IN THE PREGNANT RAT. Am J Physiol. 1964; 206:796-804. DOI: 10.1152/ajplegacy.1964.206.4.796. View

18.

Knopp R, Saudek C, Arky R, OSullivan J . 2 phases of adipose tissue metabolism in pregnancy: maternal adaptations for fetal growth. Endocrinology. 1973; 92(4):984-8. DOI: 10.1210/endo-92-4-984. View