Influence of Uranyl Nitrate Upon Tubular Reabsorption and Glomerular Filtration in Blood Perfused Isolated Dog Kidneys

Overview

Journal Pflugers Arch

Specialty Physiology

Date 1981 Oct 1

PMID 7312561

Citations 3

Authors

A Nizet

Affiliations

Soon will be listed here.

Abstract

The early changes in tubular reabsorption, glomerular filtration, blood flow and sodium excretion brought about by uranyl nitrate were investigated in isolated, blood-perfused dog kidneys during water diuresis. No significant changes in urine volume were observed; the decrease in fluid reabsorption was counterbalanced quantitatively by a reduction in glomerular filtration rate; only a small diminution of renal blood flow was found. The balance between reabsorption and filtration was observed as well when angiotensin action or prostaglandin synthesis were inhibited. The intrarenal venous pressure rose, suggesting that an increase in proximal intratubular hydrostatic pressure caused the decrease in filtration. Tubular back-leak of fluid, or back-diffusion, induced by the toxin, were excluded. The presence of natriuretic compounds in the urine was confirmed.

Citing Articles

Regulation of renal blood flow by plasma chloride.

Wilcox C J Clin Invest. 1983; 71(3):726-35.

PMID: 6826732 PMC: 436923. DOI: 10.1172/jci110820.

The effect of experimentally-induced renal failure on accumulation of bupropion and its major basic metabolites in plasma and brain of guinea pigs.

DeVane C, Laizure S, Cameron D Psychopharmacology (Berl). 1986; 89(4):404-8.

PMID: 3092270 DOI: 10.1007/BF02412111.

Differential effects of the degree of renal damage on p-aminohippuric acid and inulin clearances in rats.

Gloff C, Benet L J Pharmacokinet Biopharm. 1989; 17(2):169-77.

PMID: 2795454 DOI: 10.1007/BF01059026.

References

Nizet A, CUYPERS Y, Deetjen P, Kramer K . Functional capacity of the isolated perfused dog kidney. Pflugers Arch Gesamte Physiol Menschen Tiere. 1967; 296(3):179-95. DOI: 10.1007/BF00363758. View

Nizet A . Quantitative influence of non-hormonal blood factors on the control of sodium excretion by the isolated dog kidney. Kidney Int. 1972; 1(1):27-37. DOI: 10.1038/ki.1972.5. View

CUYPERS Y, Nizet A, BAERTEN A . [Technic for the perfusion of isolated dog kidneys with heparinized blood]. Arch Int Physiol Biochim. 1964; 72(2):245-55. DOI: 10.3109/13813456409058970. View

Stowe N, Schnermann J, Hermle M . Feedback regulation of nephron filtration rate during pharmacologic interference with the renin-angiotensin and adrenergic systems in rats. Kidney Int. 1979; 15(5):473-86. DOI: 10.1038/ki.1979.63. View

Stein J, Gottschall J, Osgood R, FERRIS T . Pathophysiology of a nephrotoxic model of acute renal failure. Kidney Int. 1975; 8(1):27-41. DOI: 10.1038/ki.1975.73. View

Ploth D, Rudulph J, LAGRANGE R, Navar L . Tubuloglomerular feedback and single nephron function after converting enzyme inhibition in the rat. J Clin Invest. 1979; 64(5):1325-35. PMC: 371280. DOI: 10.1172/JCI109589. View

Nizet A . Influence of replacement of chloride by sulphate upon urine excretion and glomerular filtration rate in blood perfused isolated dog kidneys. Pflugers Arch. 1979; 382(3):217-23. DOI: 10.1007/BF00583705. View

Flamenbaum W, Hamburger R, Kaufman J . Distal Tubule [Na+] and juxtaglomerular apparatus Renin activity in uranyl nitrate induced acute renal failure in the rat. An evaluation of the role of tubuloglomerular feedback. Pflugers Arch. 1976; 364(3):209-15. DOI: 10.1007/BF00581757. View

Kleinman J, MCNEIL J, Flamenbaum W . Uranyl nitrate acute renal failure in the dog: early changes in renal function and haemodynamics. Clin Sci Mol Med. 1975; 48(1):9-16. DOI: 10.1042/cs0480009. View

10.

Deetjen P . [MICROPUNCTURE STUDIES ON THE EFFECT OF FUROSEMIDE]. Pflugers Arch Gesamte Physiol Menschen Tiere. 1965; 284:184-90. View

11.

Vanherweghem J, Ducobu J, Dhollander A . Effects of indomethacin on renal hemodynamics and on water and sodium excretion by the isolated dog kidney. Pflugers Arch. 1975; 357(3-4):243-52. DOI: 10.1007/BF00585979. View

12.

Burg M, Stoner L, Cardinal J, Green N . Furosemide effect on isolated perfused tubules. Am J Physiol. 1973; 225(1):119-24. DOI: 10.1152/ajplegacy.1973.225.1.119. View

13.

Clarkson E, Raw S, DE WARDENER H . Two natriuretic substances in extracts of urine from normal man when salt-depleted and salt-loaded. Kidney Int. 1976; 10(5):381-94. DOI: 10.1038/ki.1976.124. View

14.

Mason J . Tubulo-glomerular feedback in the early stages of experimental acute renal failure. Kidney Int Suppl. 1976; 6:S106-14. View

15.

Blantz R . The mechanism of acute renal failure after uranyl nitrate. J Clin Invest. 1975; 55(3):621-35. PMC: 301791. DOI: 10.1172/JCI107970. View

16.

SELKURT E, Deetjen P, Brechtelsbauer H . Tubular pressure gradients and filtration dynamics during urinary stop flow in the rat. Pflugers Arch Gesamte Physiol Menschen Tiere. 1965; 286(1):19-35. DOI: 10.1007/BF00362678. View

17.

Olbricht C, Mason J, Takabatake T, Hohlbrugger G, Thurau K . The early phase of experimental acute renal failure. II. tubular leakage and the reliability of glomerular markers. Pflugers Arch. 1977; 372(3):251-8. DOI: 10.1007/BF01063860. View

18.

RECTOR Jr F, VANGIESEN G, KIIL F, SELDIN D . INFLUENCE OF EXPANSION OF EXTRACELLULAR VOLUME ON TUBULAR REABSORPTION OF SODIUM INDEPENDENT OF CHANGES IN GLOMERULAR FILTRATION RATE AND ALDOSTERONE ACTIVITY. J Clin Invest. 1964; 43:341-8. PMC: 441927. DOI: 10.1172/JCI104919. View

19.

MARTINO J, Earley L . Relationship between intrarenal hydrostatic pressure and hemodynamically induced changes in sodium excretion. Circ Res. 1968; 23(3):371-86. DOI: 10.1161/01.res.23.3.371. View

20.

Riley A, Alexander E, MIGDAL S, LEVINSKY N . The effect of ischemia on renal blood flow in the dog. Kidney Int. 1975; 7(1):27-34. DOI: 10.1038/ki.1975.4. View