Correlation of Serum and Saliva Theophylline Concentration After Administration of a Sustained Release Preparation

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1981 Jan 1

PMID 7308276

Citations 4

Authors

J H Jonkman

G H Koeter

R Schoenmaker

K de Vries

J E Greving

R A de Zeeuw

Affiliations

Soon will be listed here.

Abstract

The correlation between serum and saliva levels of theophylline was investigated in seven healthy volunteers after multiple dose administration of a low dose (300 mg/day) and a high dose (900 mg/day) of a sustained release theophylline preparation (Theo-Dur). Tablets were taken for five days, at 8 a. m. and 8 p. m. and a last dose was taken on Day 6 at 8 a. m. Fourteen serum and saliva samples were collected simultaneously during the dosing period and for up to 32 h after the last dose. On the 300 mg/day regimen the level in saliva was 55.3% of the serum level, with an overall variability of 6.7% and an intrasubject variability of 10.5%. After 900 mg/day, the saliva concentration was 55.5% of the serum concentration, with an overall variability of 7.6% and an intrasubject variability of 12.7%. A good correlation was found between both determinations (r = 0.99), which suggests that saliva levels could be used to monitor theophylline after administration of a sustained release tablet.

Citing Articles

Pharmacokinetics of sustained release theophylline in low and high multidose regimens.

Koeter G, Jonkman J, de Vries K, Schoenmaker R, Greving J, de Zeeuw R Br J Clin Pharmacol. 1981; 12(5):647-51.

PMID: 7332728 PMC: 1401956. DOI: 10.1111/j.1365-2125.1981.tb01283.x.

Reproducibility of saliva and plasma theophylline levels following single dose administration of two sustained release preparations.

Jackson A, Edwards C, Cope A, Stockley R, Purkiss R Br J Clin Pharmacol. 1983; 15(4):407-10.

PMID: 6849775 PMC: 1427805. DOI: 10.1111/j.1365-2125.1983.tb01522.x.

Theophylline.

ELLIS E Clin Rev Allergy. 1983; 1(1):73-85.

PMID: 6367926 DOI: 10.1007/BF02991318.

Effect of a new quinolone, sparfloxacin, on the pharmacokinetics of theophylline in asthmatic patients.

Takagi K, Yamaki K, Nadai M, Kuzuya T, Hasegawa T Antimicrob Agents Chemother. 1991; 35(6):1137-41.

PMID: 1929255 PMC: 284300. DOI: 10.1128/AAC.35.6.1137.

References

Mangione A, Imhoff T, Lee R, Shum L, Jusko W . Pharmacokinetics of theophylline in hepatic disease. Chest. 1978; 73(5):616-22. DOI: 10.1378/chest.73.5.616. View

Galant S, Gillman S, CUMMINS L, Kozak P, Orcutt J . Reliability of salivary theophylline as a guide to plasma theophylline levels. Am J Dis Child. 1977; 131(9):970-2. DOI: 10.1001/archpedi.1977.02120220036004. View

Hendeles L, Burkey S, Bighley L, Richardson R . Unpredictability of theophylline saliva measurements in chronic obstructive pulmonary disease. J Allergy Clin Immunol. 1977; 60(6):335-8. DOI: 10.1016/0091-6749(77)90063-x. View

Weinberger M, Hendeles L, Bighley L . The relation of product formulation to absorption of oral theophylline. N Engl J Med. 1978; 299(16):852-7. DOI: 10.1056/NEJM197810192991603. View

Posti J . [Drug concentrations in plasma and saliva--physiologic and pharmacokinetic considerations]. Pharm Acta Helv. 1979; 54(7-8):191-6. View

Boobis S, Trembath P . Plasma-saliva ratio of theophylline following oral theophylline derivatives [proceedings]. Br J Clin Pharmacol. 1978; 6(5):456P-457P. DOI: 10.1111/j.1365-2125.1978.tb04627.x. View

Levy G, ELLIS E, Koysooko R . Indirect plasma-theophylline monitoring in asthmatic children by determination of theophylline concentration in saliva. Pediatrics. 1974; 53(6):873-6. View

Jonkman J, BERG W, Schoenmaker R, de Zeeuw R, Greving J, ORIE N . Disposition and clinical pharmacokinetics of microcrystalline theophylline. Eur J Clin Pharmacol. 1980; 17(5):379-84. DOI: 10.1007/BF00558452. View

Koysooko R, ELLIS E, Levy G . Relationship between theophylline concentration in plasma and saliva of man. Clin Pharmacol Ther. 1974; 15(5):454-60. DOI: 10.1002/cpt1974155454. View

10.

Cohen A, JOHNSON C, Re O . A rapidly dissolving theophylline tablet. Curr Ther Res Clin Exp. 1975; 17(5):497-505. View

11.

Eney R, GOLDSTEIN E . Compliance of chronic asthmatics with oral administration of theophylline as measured by serum and salivary levels. Pediatrics. 1976; 57(4):513-7. View

12.

Piafsky K, Sitar D, Rangno R, OGILVIE R . Theophylline disposition in patients with hepatic cirrhosis. N Engl J Med. 1977; 296(26):1495-7. DOI: 10.1056/NEJM197706302962603. View

13.

SCHACK J, WAXLER S . An ultraviolet spectrophotometric method for the determination of theophylline and theobromine in blood and tissues. J Pharmacol Exp Ther. 1949; 97(3):283-91. View

14.

Koeter G, Jonkman J, de Vries K, Schoenmaker R, Greving J, de Zeeuw R . Pharmacokinetics of sustained release theophylline in low and high multidose regimens. Br J Clin Pharmacol. 1981; 12(5):647-51. PMC: 1401956. DOI: 10.1111/j.1365-2125.1981.tb01283.x. View

15.

Khanna N, Bada H, Somani S . Use of salivary concentrations in the prediction of serum caffeine and theophylline concentrations in premature infants. J Pediatr. 1980; 96(3 Pt 1):494-9. DOI: 10.1016/s0022-3476(80)80708-6. View

16.

Aranda J, Sitar D, Parsons W, Loughnan P, NEIMS A . Pharmacokinetic aspects of theophylline in premature newborns. N Engl J Med. 1976; 295(8):413-6. DOI: 10.1056/NEJM197608192950803. View

17.

Lena S, Hutchins P, Wood C, Turner P . Salivary theophylline estimation in the management of asthma in children. Postgrad Med J. 1980; 56(652):85-7. PMC: 2425508. DOI: 10.1136/pgmj.56.652.85. View

18.

Danhof M, Breimer D . Therapeutic drug monitoring in saliva. Clin Pharmacokinet. 1978; 3(1):39-57. DOI: 10.2165/00003088-197803010-00003. View