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Mechanism of Hydroxylation of Biphenyl by Cunninghamella Echinulata

Overview
Journal Biochem J
Specialty Biochemistry
Date 1981 Apr 15
PMID 7306077
Citations 1
Authors
R V Smith
P J Davis
A M Clark
S K Prasatik
Affiliations
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Abstract

The hydroxylation of [U-2H]biphenyl and [2,2',3,3',5,5',6,6'-2H]biphenyl by Cunninghamella echinulata A.T.C.C. 9244 has been studied. G.l.c.-mass-spectrometry analyses indicate the lack of an isotope effect during the hydroxylation of the perdeuterated substrate. Both g.l.c.-mass spectrometry and 1H n.m.r. were used to definitively demonstrate the presence of a 1,2-hydride-shift during the microbiological hydroxylation of [2,2',3,3',5,5',6,6'-2H]biphenyl.

Citing Articles

Microbial models of mammalian metabolism: O-dealkylation of para-alkoxybiphenyls.

Smith R, Milton S, Davis P Appl Environ Microbiol. 1982; 44(1):149-52.

PMID: 6812499 PMC: 241982. DOI: 10.1128/aem.44.1.149-152.1982.

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