Gyrate Atrophy of the Retina and Choroid. Two Methods for Prenatal Diagnosis

Overview

Journal Int Ophthalmol

Specialty Ophthalmology

Date 1981 Aug 1

PMID 7298261

Authors

J J ODonnell

I Sipila

A Vannas

R SANDMAN

Affiliations

Soon will be listed here.

Abstract

We report two methods for prenatal diagnosis of gyrate atrophy of the retina and choroid caused by an inborn error of ornithine aminotransferase activity. A high pressure liquid chromatography assay measures ornithine aminotransferase accurately and directly in cultured amniotic fluid cells. The differential incorporation of 14C-ornithine and 3H-leucine into cell protein measures OAT directly but rapidly and simply.

References

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