Effect of Carbenoxolone on the Synthesis of Glycoproteins and DNA in Rat Gastric Epithelial Cells

Overview

Journal Gut

Specialty Gastroenterology

Date 1981 Oct 1

PMID 7297910

Citations 1

Authors

G A Van Huis

M F Kramer

Affiliations

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Abstract

The influence of carbenoxolone on the synthesis of glycoproteins in the surface mucous cells and the production of new cells in the rat gastric mucosa was studied by means of a vascular perfusion system. The rate of incorporation of tritiated galactose, glucosamine, serine, and sulphate in surface mucous cells, studied by autoradiography, was not affected by the addition of carbenoxolone to the drinking water. The sugar composition (determined by gas-liquid chromatography) of the gastric glycoproteins (isolated by centrifugation in CsCl), was not changed in carbenoxolone-treated rats. Compared with untreated animals, the number of [3H]-thymidine labelled nuclei per fundic pit increased by 38% to 76% in carbenoxolone-treated rats, implying a higher number of mitotically active cells. This results in an increased supply of young mucous cells; if this also proves to be true in human gastric mucosa, it may be relevant to the therapeutic effect of carbenoxolone.

Citing Articles

A study on the cell kinetics of the canine gastric mucosa by the cytofluorometric method: an evaluation of chemically induced gastric cancer.

Amano Y, Fukumoto S Gastroenterol Jpn. 1987; 22(3):292-302.

PMID: 3040508 DOI: 10.1007/BF02774255.

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