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Development of Coloboma (Cm/+), a Mutation with Anterior Lens Adhesion

Overview
Journal Anat Embryol (Berl)
Specialties Anatomy & Histology
Reproductive Medicine
Date 1981 Jan 1
PMID 7283170
Citations 12
Authors
K Theiler
D S Varnum
Affiliations
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Abstract

A semidominant mutation in the laboratory mouse, Coloboma (Cm), is described. Coloboma is located on Chromosome 2, as is the similar mutation Dickie's small eye (Dey). Coloboma has a moderately reduced expressivity. The anterior chamber is usually present in Cm/+. Both Cm and Dey show delayed detachment of the lens vesicle and microphthalmia, and homozygotes of both apparently die early in pregnancy.

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