Different Thermal Behavior of Neonatal Hepatic and Cerebral 3-hydroxy-3-methylglutaryl-CoA Reductase

Overview

Journal Lipids

Specialty Biochemistry

Date 1981 Jul 1

PMID 7278516

Citations 3

Authors

H Ramirez

M J Alejandre

J L Segovia

E Garcia-Peregrin

Affiliations

Soon will be listed here.

Abstract

The Arrhenius plots of hepatic and cerebral 3-hydroxy-3-methylglutaryl-CoA reductase activity were studied in neonatal chicks fed with a standard diet. Supplementation of the diet with 2% cholesterol from hatching has no effect on the thermal characteristics of the brain enzyme. The Arrhenius plot of brain reductase was practically similar to that found in control chicks. However, hepatic reductase was inhibited by cholesterol feeding. Dietary cholesterol increased the cholesterol/lipidic phosphorus molar ratio in liver microsomes, whereas no significant differences were observed in brain microsomes. These results are in agreement with the hypothesis that activity of hepatic reductase is regulated by the fluidity of microsomal membrane and show that cholesterol feeding does not alter the fluidity of microsomal membranes in neonatal chick brain having, thus, no effect on the thermal behavior of cerebral reductase.

Citing Articles

Development of the diurnal rhythm of chick 3-hydroxy-3-methylglutaryl-CoA reductase.

Ramirez H, Alejandre M, Garcia-Peregrin E Lipids. 1982; 17(6):434-6.

PMID: 7202099 DOI: 10.1007/BF02535222.

Inhibition of brain and liver 3-hydroxy-3-methylglutaryl-CoA reductase and mevalonate-5-pyrophosphate decarboxylase in experimental hyperphenylalaninemia.

Castillo M, Zafra M, Garcia-Peregrin E Neurochem Res. 1988; 13(6):551-5.

PMID: 3405380 DOI: 10.1007/BF00973296.

Effect of phenylalanine derivatives on the main regulatory enzymes of hepatic cholesterogenesis.

Castillo M, Zafra M, Garcia-Peregrin E Mol Cell Biochem. 1991; 105(1):21-5.

PMID: 1922006 DOI: 10.1007/BF00230371.

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