Striatal Dopamine Turnover and L-dopa Treatment After Short-term Exposure of Rats to Manganese

Overview

Journal Arch Toxicol

Specialty Toxicology

Date 1981 Jun 1

PMID 7271447

Citations 4

Authors

G S Shukla

S V CHANDRA

Affiliations

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Abstract

The turnover rate of striatal dopamine (DA) and the effect of L-dopa treatment was investigated in rats after the daily oral administration of MnCl2 . 4H20 for a period of 30 days. The turnover rate of striatal DA, as determined by the administration of alpha-methyl-p-tyrosine, increased significantly in manganese-exposed rats. L-Dopa administration resulted in a significant elevation in the levels of DA and its metabolite, homovanillic acid, in manganese-exposed rats, but these neurochemical changes could not be correlated with the concentration of manganese in the striatum. We therefore advise the L-dopa therapy should not be tried in early manganese intoxication, as it may aggravate manic symptoms due to marked increase in brain DA.

Citing Articles

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Urinary excretion of homovanillic acid in workers exposed to manganese.

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