Platelet-tissue Interaction: Role of Platelet-activating Factor (PAF-acether)

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1980 Dec 1

PMID 7270336

Citations 4

Authors

B B Vargaftig

M Chignard

J Lefort

J Benveniste

Affiliations

Soon will be listed here.

Abstract

The platelet-activating factor, or PAF-acether, is a phospholipid derivative that is a potent aggregating agent. It is formed by platelets themselves and also by basophils, neutrophils, monocytes and macrophages including alveolar macrophages. A role for PAF-acether during inflammation is envisaged since its intravenous administration induces hypotension, thrombocytopenia and bronchoconstriction in anaesthetized guinea-pigs. It is hypothesized that platelets, which contain and synthetize many pro-inflammatory substances, play a primary role in some pathological states.

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