PH of Mucus in Rat Trachea
Overview
Authors
Affiliations
The pH of the mucous coat of the trachea was measured in vivo through a tracheal window in anesthetized rats. Readings ranged from 7.42 to 7.57 and averaged 7.52 +/- 0.05 (SD) pH units. Injections of pilocarpine (cholinomimetic) were followed by a statistically significant decrease in pH to 7.46 +/- 0.05 (SD) and a subsequent return to initial values. These readings are in the region of what is accepted as the gel point of mucus. This closeness to the inflection point between sol and gel was not reported before and may explain some of the in situ flow properties of mucus.
Mechanisms of acid and base secretion by the airway epithelium.
Fischer H, Widdicombe J J Membr Biol. 2006; 211(3):139-50.
PMID: 17091214 PMC: 2929530. DOI: 10.1007/s00232-006-0861-0.
Slaughter M, Aiello E Cell Tissue Res. 1982; 227(2):413-21.
PMID: 6983908 DOI: 10.1007/BF00210895.
pH of mucus in rabbit trachea: cholinergic stimulation and block.
Gatto L Lung. 1985; 163(2):109-15.
PMID: 3927070 DOI: 10.1007/BF02713812.
Effects of inhaled acids on respiratory tract defense mechanisms.
SCHLESINGER R Environ Health Perspect. 1985; 63:25-38.
PMID: 3908089 PMC: 1568494. DOI: 10.1289/ehp.856325.