Theophylline Absorption by Effervescent Activated Charcoal (Medicoal)

Overview

Journal J Int Med Res

Publisher Sage Publications

Specialty General Medicine

Date 1981 Jan 1

PMID 7238997

Citations 4

Authors

M Helliwell

D Berry

Affiliations

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Abstract

Plasma theophylline concentrations were measured in six volunteers given 675 mg of a sustained-release preparation (Phyllocontin). Significant reductions in both the mean recorded peak theophylline plasma concentrations and the mean 12-hour theophylline bioavailability were observed after the administration of effervescent activated charcoal (Medicoal) in single and multiple doses. These results indicate the potential use of activated charcoal in the management of theophylline poisoning.

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Clinical pharmacokinetics of oral activated charcoal in acute intoxications.

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Comparison of activated charcoal and ipecac syrup in prevention of drug absorption.

Neuvonen P, Vartiainen M, Tokola O Eur J Clin Pharmacol. 1983; 24(4):557-62.

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Acute overdose with sustained release drug formulations. Perspectives in treatment.

Minocha A, Spyker D Med Toxicol. 1986; 1(4):300-7.

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Role of extracorporeal drug removal in acute theophylline poisoning. A review.

Heath A, Knudsen K Med Toxicol Adverse Drug Exp. 1987; 2(4):294-308.

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