Development of a Model for Integrated Pharmacokinetic and Pharmacodynamic Studies of Intravenous Anaesthetic Agents: Applications to Minaxolone

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1981 Jan 1

PMID 7238566

Citations 5

Authors

L E Mather

L T Seow

J G Roberts

G K Gourlay

M J Cousins

Affiliations

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Citing Articles

A pharmacokinetic-pharmacodynamic model for quantal responses with thiopental.

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Determination of pharmacokinetic constants after multiple infusions of drugs.

Mather L, Ringrose R, Austin K Eur J Clin Pharmacol. 1982; 23(4):353-8.

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Pharmacodynamic modeling of thiopental anesthesia.

Stanski D, Hudson R, Homer T, SAIDMAN L, Meathe E J Pharmacokinet Biopharm. 1984; 12(2):223-40.

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Systems dynamics in clinical pharmacokinetics. An introduction.

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Pharmacodynamic modelling. Application to new drug development.

Kroboth P, Schmith V, Smith R Clin Pharmacokinet. 1991; 20(2):91-8.

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References

Dundee J, Moore J . Thiopentone and methohexital, a comparison as main anaesthetic agents for a standard operation. Anaesthesia. 1961; 16:50-60. View

Carson I, Dundee J, Clarke R . The speed of onset and potency of althesin. Br J Anaesth. 1975; 47(4):512-5. DOI: 10.1093/bja/47.4.512. View

Holdcroft A, Morgan M, WHITWAM J, Lumley J . Effect of dose and premedication on induction complications with etomidate. Br J Anaesth. 1976; 48(3):199-205. DOI: 10.1093/bja/48.3.199. View

Ghoneim M, Van Hamme M . Pharmacokinetics of thiopentone: effects of enflurane and nitrous oxide anaesthesia and surgery. Br J Anaesth. 1978; 50(12):1237-42. DOI: 10.1093/bja/50.12.1237. View

WHITWAM J, Manners J . Clinical comparison of thiopentone and methohexitone. Br Med J. 1962; 1(5293):1663-5. PMC: 1958858. DOI: 10.1136/bmj.1.5293.1663. View

Breimer D . Pharmacokinetics of methohexitone following intravenous infusion in humans. Br J Anaesth. 1976; 48(7):643-9. DOI: 10.1093/bja/48.7.643. View

Aveling W, Sear J, Fitch W, Chang H, Waters A, Cooper G . Early clinical evaluation of minaxolone: a new intravenous steroid anaesthetic agent. Lancet. 1979; 2(8133):71-3. DOI: 10.1016/s0140-6736(79)90122-3. View

BECKETT A . Maternal and neonatal metabolism of analgesic drugs. Br J Anaesth. 1973; 45:Suppl:770-81. View

McNeill H, Clarke R, Dundee J . Minaxolone: a new water-soluble steroid anaesthetic. Lancet. 1979; 2(8133):73-4. DOI: 10.1016/s0140-6736(79)90123-5. View

10.

Doenicke A, Krumey I, Kugler J, Klempa J . Experimental studies of the breakdown of Epontol: determination of propanidid in human serum. Br J Anaesth. 1968; 40(6):415-29. DOI: 10.1093/bja/40.6.415. View

11.

Dundee J, Clarke R . CLINICAL STUDIES OF INDUCTION AGENTS. IX. A COMPARATIVE STUDY OF A NEW EUGENOL DERIVATIVE, FBA.1420, WITH G.29.505 AND STANDARD BARBITURATES. Br J Anaesth. 1964; 36:100-5. DOI: 10.1093/bja/36.2.100. View

12.

. Comparative recovery rates following induction of anaesthesia with Althesin and methohexitone in out-patients. Postgrad Med J. 1972; 48:Suppl 2:116-20. View

13.

Zito R, Reid P . Lidocaine kinetics predicted by indocyanine green clearance. N Engl J Med. 1978; 298(21):1160-3. DOI: 10.1056/NEJM197805252982102. View

14.

Clarke R, Dundee J, Carson I . Some aspects of the clinical pharmacology of Althesin. Postgrad Med J. 1972; 48:Suppl 2:62-5. View

15.

Vickers M . THE MEASUREMENT OF RECOVERY FROM ANAESTHESIA. Br J Anaesth. 1965; 37:296-302. DOI: 10.1093/bja/37.5.296. View

16.

Young D, WHITWAM J . OBSERVATIONS ON DENTAL ANAESTHESIA INTRODUCED WITH METHOHEXITONE. I. INDUCTION OF ANAESTHESIA. Br J Anaesth. 1964; 36:31-8. DOI: 10.1093/bja/36.1.31. View

17.

Van Hamme M, Ghoneim M, Ambre J . Pharmacokinetics of etomidate, a new intravenous anesthetic. Anesthesiology. 1978; 49(4):274-7. DOI: 10.1097/00000542-197810000-00010. View

18.

Moore J, Dundee J . Promethazine, its influence on the course of thiopentone and methohexital anaesthesia. Anaesthesia. 1961; 16:61-73. DOI: 10.1111/j.1365-2044.1961.tb13375.x. View

19.

Dundee J . Editorial: Hypersensitivity to intravenous anaesthetic agents. Br J Anaesth. 1976; 48(2):57-8. DOI: 10.1093/bja/48.2.57. View

20.

CHILD K, CURRIE J, Dis B, Dodds M, Pearce D, Twissell D . The pharmacological properties in animals of CT1341--a new steroid anaesthetic agent. Br J Anaesth. 1971; 43(1):2-13. DOI: 10.1093/bja/43.1.2-a. View