A New Concept in the Management of Marjolin's Ulcers

Overview

Journal Ann Surg

Specialty General Surgery

Date 1981 May 1

PMID 7235765

Citations 8

Authors

R F RYAN

M S Litwin

E T Krementz

Affiliations

Soon will be listed here.

Abstract

Marjolin's ulcers have a grave prognosis, especially when regional nodes are involved. Recent studies suggest such cancers are in an immunologically privileges sites due to the dense scar tissue. The prognosis has been shown to be much worse for tumors not having a round cell infiltrate prior to surgery, as in Marjolin's ulcers. The use of topical 5-fluorouracil (5-FU) induces a round cell infiltrate. Three case reports of large Marjolin's ulcers are presented which were first treated with topical 5-FU. Radical ablative surgery was avoided in these patients with a successful outcome.

Citing Articles

Marjolin's ulcer: clinical and pathologic features of 83 cases and review of literature.

Fazeli M, Lebaschi A, Hajirostam M, Keramati M Med J Islam Repub Iran. 2014; 27(4):215-24.

PMID: 24926183 PMC: 4011412.

Cutaneous squamous cell carcinoma (SCC) arising in stump of amputated finger in a patient with resected glossal SCC.

Uchida K, Miyazaki T, Nakajima H, Negoro K, Sugita D, Watanabe S BMC Res Notes. 2012; 5:595.

PMID: 23111060 PMC: 3607937. DOI: 10.1186/1756-0500-5-595.

Marjolin ulcer: an overlooked entity.

Pavlovic S, Wiley E, Guzman G, Morris D, Braniecki M Int Wound J. 2011; 8(4):419-24.

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Marjolin's ulcers: theories, prognostic factors and their peculiarities in spina bifida patients.

Nthumba P World J Surg Oncol. 2010; 8:108.

PMID: 21129225 PMC: 3014936. DOI: 10.1186/1477-7819-8-108.

Development of Marjolin's ulcer within one month of burn injury with synchronous primary lung squamous cell carcinoma in an elderly patient: report of a case with allelotyping.

Wooldridge A, Griesser M, Scharschmidt T, Iwenofu O Med Oncol. 2010; 28 Suppl 1:S586-92.

PMID: 21086072 DOI: 10.1007/s12032-010-9744-4.

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