To the Problem of Biologically Active Conformation of Enkephalin

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 1981 Jan 20

PMID 7231396

Citations 4

Authors

I Z Siemion

Z Szewczuk

Z S Herman

Z Stachura

Affiliations

Soon will be listed here.

Abstract

A semi-rigid structural analog of [Leu5] enkephalin, possessing the azo-bridge between Tyr1 and Phe4 residues, was synthesized, along with two other linear enkephalin analogs: [4'-amino Phe4] enkephalin and [4'/hydroxyphenyl/-azo Phe4] enkephalin. The results of the determination of the analgesic activity of the synthesized compounds suggest that the biologically active conformation of the enkephalin molecule should be such that both aromatic rings, Tyr1 and Phe4, are situated in close proximity.

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References

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