Induction by Progesterone of a Sexual Dimorphism of Estrogen Uptake by Anterior Pituitary Cells in Situ

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 1981 Jan 1

PMID 7226200

Citations 3

Authors

D A Keefer

Affiliations

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Abstract

The effects of progesterone pretreatment on in vivo 3H-estrogen uptake by five anterior pituitary cell types was analyzed by means of a quantitative autoradiographic-immunocytochemical technique. Male and female rats castrated for 14 days show nuclear concentration of label in all five cell types one h after injection of 3H-estradiol, whether progesterone treated or not. The order of labeling intensity is gonadotropes greater than or equal to lactotropes = somatotropes greater than thyrotropes = corticotropes. Progesterone treatment induces a dramatic sexual dimorphism in estrogen uptake; it significantly increases 3H-estrogen uptake in all female cell types. In males, progesterone decreases uptake in gonadotropes while not altering uptake in other cell types.

Citing Articles

Does neonatal androgen modulate uptake and retention of 3H-estradiol in gonadotrophs and lactotrophs?.

Nogami H, Yoshimura F, Herbert D, Sheridan P Cell Tissue Res. 1985; 242(3):629-32.

PMID: 4075382 DOI: 10.1007/BF00225429.

Dihydrotestosterone induces a sexual dimorphism in estrogen uptake by specific anterior pituitary cell types in vivo.

Keefer D, Dordai N, Mallonga R, Ziegler K, Shughrue P, Ramirez P Cell Tissue Res. 1987; 249(2):477-9.

PMID: 3621311 DOI: 10.1007/BF00215534.

Uptake and retention of 3H-estradiol by gonadotrophs and lactotrophs in the pituitary glands of the guinea pig, hamster and gerbil.

Nogami H, Herbert D, WINBORN W, Weaker F, Sheridan P Cell Tissue Res. 1987; 248(1):75-8.

PMID: 3568118 DOI: 10.1007/BF01239965.

References

Moguilewsky M, Raynaud J . Progestin binding sites in the rat hypothalamus pituitary and uterus. Steroids. 1977; 30(1):99-109. DOI: 10.1016/0039-128x(77)90140-4. View

Negro-Vilar A, ORIAS R, McCANN S . Evidence for a pituitary site of action for the acute inhibition of LH release by estrogen in the rat. Endocrinology. 1973; 92(6):1680-4. DOI: 10.1210/endo-92-6-1680. View

Merimee T, FINEBERG S . Studies of the sex based variation of human growth hormone secretion. J Clin Endocrinol Metab. 1971; 33(6):896-902. DOI: 10.1210/jcem-33-6-896. View

MENON K, Gunaga K . Cytoplasmic and nuclear receptor-estradiol complex in the hipothalamus and pituitary: relationship with pituitary sensitivity to gonadotropin releasing hormone and gonadotropin secretion in the rat. Neuroendocrinology. 1976; 22(1):8-17. DOI: 10.1159/000122608. View

Feder H, Marrone B . Progesterone: its role in the central nervous system as a facilitator and inhibitor of sexual behavior and gonadotropin release. Ann N Y Acad Sci. 1977; 286:331-54. DOI: 10.1111/j.1749-6632.1977.tb29428.x. View

Gershengorn M, Geras E . Estrogens increase the number of thyrotropin-releasing hormone receptors on mammotropic cells in culture. Endocrinology. 1979; 105(1):171-6. DOI: 10.1210/endo-105-1-171. View

BOGDANOVE E . DIRECT GONAD-PITUITARY FEEDBACK: AN ANALYSIS OF EFFECTS OF INTRACRANIAL ESTROGENIC DEPOTS ON GONADOTROPHIN SECRETION. Endocrinology. 1963; 73:696-712. DOI: 10.1210/endo-73-6-696. View

FRANTZ A, Rabkin M . Effects of estrogen and sex difference on secretion of human growth hormone. J Clin Endocrinol Metab. 1965; 25(11):1470-80. DOI: 10.1210/jcem-25-11-1470. View

Zigmond R, McEwen B . Selective retention of oestradiol by cell nuclei in specific brain regions of the ovariectomized rat. J Neurochem. 1970; 17(7):889-99. DOI: 10.1111/j.1471-4159.1970.tb02242.x. View

10.

Badger T, Wilcox C, Meyer E, Bell R, Cicero T . Simultaneous changes in tissue and serum levels of luteinizing hormone, follicle-stimulating hormone, and luteinizing hormone/follicle-stimulating hormone releasing factor after castration in the male rat. Endocrinology. 1978; 102(1):136-41. DOI: 10.1210/endo-102-1-136. View

11.

Libertun C, Cooper K, FAWCETT C, McCANN S . Effects of ovariectomy and steroid treatment on hypophyseal sensitivity to purified LH-releasing factor (LRF). Endocrinology. 1974; 94(2):518-25. DOI: 10.1210/endo-94-2-518. View

12.

Mains R, Eipper B, Ling N . Common precursor to corticotropins and endorphins. Proc Natl Acad Sci U S A. 1977; 74(7):3014-8. PMC: 431388. DOI: 10.1073/pnas.74.7.3014. View

13.

Maclusky N, McEwen B . Progestin receptors in rat brain: distribution and properties of cytoplasmic progestin-binding sites. Endocrinology. 1980; 106(1):192-202. DOI: 10.1210/endo-106-1-192. View

14.

Fisher J, DANGELO S . Stimulatory and inhibitory action of estradiol on TSH secretion. Endocrinology. 1971; 88(3):687-91. DOI: 10.1210/endo-88-3-687. View

15.

Ramirez V, McCANN S . INDUCTION OF PROLACTIN SECRETION BY IMPLANTS OF ESTROGEN INTO THE HYPOTHALAMO-HYPOPHYSIAL REGION OF FEMALE RATS. Endocrinology. 1964; 75:206-14. DOI: 10.1210/endo-75-2-206. View

16.

Wuttke W, Meites J . Effects of ether and pentobarbital on serum prolactin and LH levels in proestrous rats. Proc Soc Exp Biol Med. 1970; 135(3):648-52. DOI: 10.3181/00379727-135-35113. View

17.

KITAY J . PITUITARY-ADRENAL FUNCTION IN THE RAT AFTER GONADECTOMY AND GONADAL HORMONE REPLACEMENT. Endocrinology. 1963; 73:253-60. DOI: 10.1210/endo-73-2-253. View

18.

Lean A, Garon M, Kelly P, Labrie F . Changes of pituitary thyrotropin releasing hormone (TRH) receptor level and prolactin response to TRH during the rat estrous cycle. Endocrinology. 1977; 100(6):1505-10. DOI: 10.1210/endo-100-6-1505. View

19.

Debeljuk L, Arimura A, Schally A . Effect of estradiol and progesterone on the LH release induced by LH-releasing hormone (LH-RH) in intact diestrous rats and anestrous ewes. Proc Soc Exp Biol Med. 1972; 139(3):774-7. DOI: 10.3181/00379727-139-36235. View

20.

Maclusky N, McEwen B . Oestrogen modulates progestin receptor concentrations in some rat brain regions but not in others. Nature. 1978; 274(5668):276-8. DOI: 10.1038/274276a0. View