Coronary Arterial Lesions in Sexually Mature Non-layers, Layers, and Roosters

Overview

Journal Virchows Arch A Pathol Anat Histol

Specialty Pathology

Date 1980 Jan 1

PMID 7210496

Citations 2

Authors

T Toda

D Leszczynski

W H McGIBBON

F A KUMMEROW

Affiliations

Soon will be listed here.

Abstract

The effects of hereditary hyperlipidemia on coronary artery atherosclerosis were studied in 77 White Leghorn (DeKalb strain) chickens ranging from 4 to 13 months in age. After pubescence, the plasma levels of triglyceride and cholesterol in non-laying hens ranged 2- to 3-fold and 2- to 7-fold higher compared to layers. Serial sectioning revealed that most lesions were found in the proximal portions of both the left and right coronary arteries. Ultrastructurally, lesions in the roosters contained no foam cells, whereas some foam cells and small amounts of stainable lipid were observed in the thickened intima of layers. Half of the non-layers had stenotic lesions characterized by many foam cells, necrotic foci, and heavy stromal lipid deposits. Continuous permeation of excess plasma lipids into the arterial wall appeared to be an important factor in the development of coronary lesions.

Citing Articles

The restricted ovulator chicken strain: an oviparous vertebrate model of reproductive dysfunction caused by a gene defect affecting an oocyte-specific receptor.

Elkin R, Bauer R, Schneider W Anim Reprod Sci. 2012; 136(1-2):1-13.

PMID: 23123285 PMC: 3521959. DOI: 10.1016/j.anireprosci.2012.10.002.

Mutant oocytic low density lipoprotein receptor gene family member causes atherosclerosis and female sterility.

Bujo H, Yamamoto T, Hayashi K, Hermann M, Nimpf J, Schneider W Proc Natl Acad Sci U S A. 1995; 92(21):9905-9.

PMID: 7568242 PMC: 40911. DOI: 10.1073/pnas.92.21.9905.

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