A Monosialoganglioside is a Monoclonal Antibody-defined Antigen of Colon Carcinoma

Overview

Journal Science

Specialty Science

Date 1981 Apr 3

PMID 7209516

Citations 68

Authors

J L Magnani

M Brockhaus

D F Smith

V Ginsburg

M Blaszczyk

K F Mitchell

Z Steplewski

H KOPROWSKI

Affiliations

Soon will be listed here.

Abstract

The antigen of a monoclonal antibody that is specific for cells of human carcinoma of the colon is a monosialoganglioside as determined by the direct binding of antibody to thin-layer chromatograms of total lipid extracts of tissues. Binding of antibody to chromatograms is detected by autoradiography after the application of iodine-125-labeled F(ab')2 of rabbit immunoglobulin G antibodies to mouse immunoglobulins.

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