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Protective Effect of Anionic Cholecystographic Agents Against Phalloidin on Isolated Hepatocytes by Competitive Inhibition of the Phallotoxin Uptake. Comparison of the Influence on the Inward Transport of 3H-demethylphalloin and of 14C-cholate

Overview
Journal Naunyn Schmiedebergs Arch Pharmacol
Specialty Pharmacology
Date 1980 Aug 1
PMID 7207638
Citations 10
Authors
M Frimmer
E Petzinger
K Ziegler
Affiliations
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Abstract

Several anionic substances used for cholecystography inhibit the development of protrusions in isolated hepatocytes in response to phalloidin. Drugs from the iopodate family were equieffective with those of th iodipamide type. The above protective effect results from a competitive inhibition of the phallotoxin uptake as shown for iopodate. Cholecystographic agents similarly inhibit the inward transport of cholic acid in a competitive manner. The inhibition of the phallotoxin response is inversely correlated with the uptake of 3H-demethylphalloin (r = 0.94) and with the inward transport of cholate (r = 0.84) at various inhibiting concentrations of iopodate.

Citing Articles

Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins.

Fehrenbach T, Cui Y, Faulstich H, Keppler D Naunyn Schmiedebergs Arch Pharmacol. 2003; 368(5):415-20.

PMID: 14530907 DOI: 10.1007/s00210-003-0814-4.

Competitive inhibition of the uptake of demethylphalloin by cholic acid in isolated hepatocytes. Evidence for a transport competition rather than a binding competition.

Petzinger E Naunyn Schmiedebergs Arch Pharmacol. 1981; 316(4):345-9.

PMID: 7266684 DOI: 10.1007/BF00501368.

Lack of intestinal transport of [3H]-demethylphalloin: comparative studies with phallotoxins and bile acids on isolated small intestinal cells and ileal brush border membrane vesicles.

Petzinger E, Burckhardt G, Schwenk M, Faulstich H Naunyn Schmiedebergs Arch Pharmacol. 1982; 320(2):196-200.

PMID: 7121618 DOI: 10.1007/BF00506321.

Affinity labels for membrane components involved in the uptake of bile acids and of phallotoxins by hepatocytes. Development of covalently binding derivatives of bile acids and of compounds related to cholecystographic agents.

Ziegler K, Frimmer M, Moller W, FASOLD H Naunyn Schmiedebergs Arch Pharmacol. 1982; 319(3):249-53.

PMID: 7110383 DOI: 10.1007/BF00495874.

Common properties of hepatocellular uptake of cholate, iodipamide and antamanide, as distinct from the uptake of bromosulfophthalein.

Petzinger E, Joppen C, Frimmer M Naunyn Schmiedebergs Arch Pharmacol. 1983; 322(2):174-9.

PMID: 6688124 DOI: 10.1007/BF00512393.

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