Synthesis and Antidepressant Activity of Substituted (omega-aminoalkoxy)benzene Derivatives

Overview

Journal J Med Chem

Publisher American Chemical Society

Specialty Chemistry

Date 1981 Feb 1

PMID 7205881

Citations 4

Authors

R Kikumoto

A TOBE

S TONOMURA

Affiliations

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Abstract

A series of substituted (omega-aminoalkoxy)benzene derivatives has been synthesized and screened for potential antidepressant activities. The effect of structural variation of these molecules has been systematically examined. Antidepressant activity was clearly displayed by 2-benzyl-1-[4-(methylamino)butoxy]benzene (7), 2-(2-hydroxybenzyl)-1-[4-(methylamino)butoxy]benzene (19), 1-[4-(methylamino)butoxy]-2-phenoxybenzene (29), and 1-[4-(methylamino)butoxy]-2-(phenylthio)benzene (31) in further pharmacological studies. These compounds did not possess the anticholinergic, antihistaminic, and muscle-relaxant side effects common to tricyclic antidepressants.

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