Influence of GABA Receptor Agonists and Antagonists on the Binding of 3H-diazepam to the Benzodiazepine Receptor

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1978 Nov 1

PMID 720385

Citations 11

Authors

M S Briley

S Z Langer

Affiliations

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Abstract

The GABA receptor agonists, GABA and muscimol, increased, while the GABA receptor antagonist, (+)-bicuculline, decreased the affinity of the benzodiazepine receptor for 3H-diazepam. The effect was seen at both 0 and 25 degrees C in spite of a large difference of affinity for 3H-diazepam at the two temperatures.

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