Enhancement of Human Chorionic Gonadotrophin Production by Antimetabolites

Overview

Journal Br J Cancer

Specialty Oncology

Date 1982 Jul 1

PMID 7201846

Citations 4

Authors

P Browne

K D Bagshawe

Affiliations

Soon will be listed here.

Abstract

The action of methotrexate, actinomycin D, bleomycin, vincristine and hydroxyurea on the production of human chorionic gonadotrophin (hCG) by a choriocarcinoma cell line (BeWo) has been studied. hCG production per unit of cell protein was increased, and this was a continuing process only halted by cell death. The proportion of hCG-producing cells in the population increased from approximately 5% to a maximum of approximately 40% during incubation with vincristine. A possible explanation for these and related observations is that cytotoxic agents promote the differentiation of cytotrophoblast to syncytium. A similar mechanism could contribute to the unusual sensitivity of choriocarcinoma to cytotoxic agents.

Citing Articles

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