Ultrastructural Aspects of Myogenesis Found in Neoplasms

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1981 Jan 1

PMID 7196673

Citations 2

Authors

F P Prince

Affiliations

Soon will be listed here.

Abstract

The ultrastructure of myogenic cells occurring in neoplasms was investigated and aspects of differentiation (myofilament interactions and organization, and sarcotubular development) were characterized. The stages of muscle differentiation present were extremely similar to those reported during human fetal development prior to innervation. Exceptions, however, being: (1) the presence of fewer multinucleated cells; (2) the general lack of cell elongation and its apparent effect on myofibril orientation; and (3) evidence of a higher number of myofilaments in mononucleated cells. The findings were compared to those reported in normal human fetal development, human myogenic cells in vitro and the literature on mammalian and avian muscle development and discussed with regard to the influence of tension and innervation. The significance of degenerating myogenic cells found in these neoplasms is also discussed.

Citing Articles

Primary rhabdomyosarcoma of brain and cerebellum. Report of four cases in infants: an immunohistochemical study.

Taratuto A, Molina H, Diez B, Zuccaro G, MONGES J Acta Neuropathol. 1985; 66(2):98-104.

PMID: 4013672 DOI: 10.1007/BF00688683.

Proliferation of myogenic cells in the diaphragm of the fetal rabbit.

Yamashiro S, Harris W, Bast T Can J Vet Res. 1986; 50(1):74-7.

PMID: 3742361 PMC: 1255162.

References

Ishikawa H, Bischoff R, Holtzer H . Mitosis and intermediate-sized filaments in developing skeletal muscle. J Cell Biol. 1968; 38(3):538-55. PMC: 2108373. DOI: 10.1083/jcb.38.3.538. View

Holtzer H, Strahs K, Biehl J, Somlyo A, Ishikawa H . Thick and thin filaments in postmitotic, mononucleated myoblasts. Science. 1975; 188(4191):943-5. DOI: 10.1126/science.1138363. View

Marosan G . Patterns of neuromuscular disease. As related to stages of normal embryogenesis in voluntary muscle. Am J Pathol. 1979; 95(2):359-78. PMC: 2042326. View

HILFER S, Searls R, Fonte V . An ultrastructural study of early myogenesis in the chick wing bud. Dev Biol. 1973; 30(2):374-91. DOI: 10.1016/0012-1606(73)90095-x. View

Edge M . Development of apposed sarcoplasmic reticulum at the T system and sarcolemma and the change in orientation of triads in rat skeletal muscle. Dev Biol. 1970; 23(4):634-50. DOI: 10.1016/0012-1606(70)90144-2. View

Fischman D . An electron microscope study of myofibril formation in embryonic chick skeletal muscle. J Cell Biol. 1967; 32(3):557-75. PMC: 2107275. DOI: 10.1083/jcb.32.3.557. View

Stahlberger R, FRIEDE R . Fine structure of myomedulloblastoma. Acta Neuropathol. 1977; 37(1):43-8. DOI: 10.1007/BF00684539. View

Tomanek R . Cytological differentiation of human fetal skeletal muscle. Am J Anat. 1977; 149(2):227-45. DOI: 10.1002/aja.1001490207. View

Kelly A, ZACKS S . The histogenesis of rat intercostal muscle. J Cell Biol. 1969; 42(1):135-53. PMC: 2107573. DOI: 10.1083/jcb.42.1.135. View

10.

Hildebrand H, BISERTE G . Ultrastructural investigation of NI3S2-induced rhabdomyosarcoma in Wistar rat: comparative study with emphasis on myofibrillar differentiation and ciliar formation. Cancer. 1978; 42(2):528-54. DOI: 10.1002/1097-0142(197808)42:2<528::aid-cncr2820420222>3.0.co;2-d. View

11.

Hanzlikova V, Schiaffino S . Studies on the effect of denervation in developing muscle. 3. Diversification of myofibrillar structure and origin of the heterogeneity of muscle fiber types. Z Zellforsch Mikrosk Anat. 1973; 147(1):75-85. DOI: 10.1007/BF00306601. View

12.

Ezerman E, Ishikawa H . Differentiation of the sarcoplasmic reticulum and T system in developing chick skeletal muscle in vitro. J Cell Biol. 2009; 35(2):405-20. PMC: 2107142. DOI: 10.1083/jcb.35.2.405. View

13.

Yagishita S, Itoh Y, Chiba Y, Fujino H . Primary rhabdomyosarcoma of the cerebrum. An ultrastructural study. Acta Neuropathol. 1979; 45(2):111-5. DOI: 10.1007/BF00691888. View

14.

Kastendieck H, Bocker W, HUSSELMANN H . [Ultrastructure and formal pathogenesis of embryonal rhabdomyosarcoma (author's transl)]. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976; 86(1):55-68. DOI: 10.1007/BF00304934. View

15.

Walker S, Edge M . The sarcoplasmic reticulum and development of Z lines in skeletal muscle fibers of fetal and postnatal rats. Anat Rec. 1971; 169(4):661-78. DOI: 10.1002/ar.1091690406. View

16.

ZIMMERMAN L, Font R, Andersen S . Rhabdomyosarcomatous differentiation in malignant intraocular medulloepitheliomas. Cancer. 1972; 30(3):817-35. DOI: 10.1002/1097-0142(197209)30:3<817::aid-cncr2820300334>3.0.co;2-e. View

17.

Mierau G, Favara B . Rhabdomyosarcoma in children: ultrastructural study of 31 cases. Cancer. 1980; 46(9):2035-40. DOI: 10.1002/1097-0142(19801101)46:9<2035::aid-cncr2820460922>3.0.co;2-2. View

18.

Walter G, BRUCHER J . Ultrastructural study of medullomyoblastoma. Acta Neuropathol. 1979; 48(3):211-4. DOI: 10.1007/BF00690521. View

19.

SAUNDERS Jr J . Death in embryonic systems. Science. 1966; 154(3749):604-12. DOI: 10.1126/science.154.3749.604. View

20.

Tremblay M . Ultrastructure of a Wilms' tumour and myogenesis. J Pathol. 1971; 105(4):269-77. DOI: 10.1002/path.1711050405. View