Alpha 2.0
Login Register
» Articles » PMID: 7192074

Symptomatic Zinc Deficiency in a Breast-fed Preterm Infant

Overview
Journal Arch Dis Child
Specialty Pediatrics
Date 1980 Jul 1
PMID 7192074
Citations 23
Authors
P J Aggett
D J Atherton
J More
J Davey
H T Delves
J T HARRIES
Affiliations
Soon will be listed here.
Abstract

A 2-month-old preterm boy who developed symptomatic zinc deficiency while being exclusively breast fed is described. Oral zinc supplements induced a complete remission but mucosal 65Zn uptake studies and metabolic balances conducted before and after withdrawal of the supplements excluded the diagnosis of acrodermatitis enteropathica. By age 12 months the boy was well and no longer required zinc supplements. Other possible causes of this patient's symptomatic zinc deficiency are discussed and these should be considered in the immediate and long-term management of preterm infants.

Citing Articles

Zinc as a Gatekeeper of Immune Function.

Wessels I, Maywald M, Rink L Nutrients. 2017; 9(12).

PMID: 29186856 PMC: 5748737. DOI: 10.3390/nu9121286.

Diagnosis of acrodermatitis enteropathica in resource limited settings.

Dev T, Sethuraman G BMJ Case Rep. 2017; 2017.

PMID: 28768674 PMC: 5623307. DOI: 10.1136/bcr-2017-220928.

Novel mutations in SLC30A2 involved in the pathogenesis of transient neonatal zinc deficiency.

Itsumura N, Kibihara Y, Fukue K, Miyata A, Fukushima K, Tamagawa-Mineoka R Pediatr Res. 2016; 80(4):586-94.

PMID: 27304099 DOI: 10.1038/pr.2016.108.

Infants and elderlies are susceptible to zinc deficiency.

Yasuda H, Tsutsui T Sci Rep. 2016; 6:21850.

PMID: 26912464 PMC: 4766432. DOI: 10.1038/srep21850.

Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk.

Kumar L, Michalczyk A, McKay J, Ford D, Kambe T, Hudek L Genes Nutr. 2015; 10(5):487.

PMID: 26319140 PMC: 4552687. DOI: 10.1007/s12263-015-0487-x.

References
1.
Meret S, Henkin R . Simultaneous direct estimation by atomic absorption spectrophotometry of copper and zinc in serum, urine, and cerebrospinal fluid. Clin Chem. 1971; 17(5):369-73. View
2.
Henkin R, Schulman J, Schulman C, Bronzert D . Changes in total, nondiffusible, and diffusible plasma zinc and copper during infancy. J Pediatr. 1973; 82(5):831-7. DOI: 10.1016/s0022-3476(73)80076-9. View
3.
WIDDOWSON E . Trace elements in foetal and early postnatal development. Proc Nutr Soc. 1974; 33(3):275-84. DOI: 10.1079/pns19740050. View
4.
Dauncey M, Shaw J, Urman J . The absorption and retention of magnesium, zinc, and copper by low birth weight infants fed pasteurized human breast milk. Pediatr Res. 1977; 11(10 Pt 1):1033-9. DOI: 10.1203/00006450-197710000-00001. View
5.
Sivasubramanian K, Henkin R . Behavioral and dermatologic changes and low serum zinc and copper concentrations in two premature infants after parenteral alimentation. J Pediatr. 1978; 93(5):847-51. DOI: 10.1016/s0022-3476(78)81099-3. View