Autonomic Nervous Control of the Heart in Exercising Man

Overview

Journal Pflugers Arch

Specialty Physiology

Date 1980 Mar 1

PMID 7189862

Citations 1

Authors

I Sato

Y Hasegawa

K Hotta

Affiliations

Soon will be listed here.

Abstract

Effects of pharmacological denervation with propranolol (0.2 mg.kg-1) and/or atropine (0.04 mg.kg-1) on the control system of heart rate during exercise were studied using a frequency domain analysis, to evaluate the cardiac control function of autonomic nervous systems in man. Propranolol decreased the gain of the system in low frequency range and increased the gain slightly in middle and high frequency ranges. The phase angle of the system was advanced over the whole frequency range observed. Atropine decreased and delayed the gain and phase angle, respectively, especially in high frequency range. The combined administration of blockades significantly decreased the gain and delayed the phase angle in the whole and high frequency ranges, respectively. These findings suggest that sympathetic and parasympathetic nervous systems act nearly independently in controlling heart rate during exercise; that they act in different manners; and that the characteristics of the systems can feasibly be used to estimate clinically the cardiac control function of autonomic nerves in man.

Citing Articles

Autonomic nervous control of the heart rate response to dynamic incremental exercise: evaluation of the Rosenblueth-Simeone model.

Ribeiro J, Ibanez J, Stein R Eur J Appl Physiol Occup Physiol. 1991; 62(2):140-4.

PMID: 2022203 DOI: 10.1007/BF00626770.

References

Fujihara Y, Hildebrandt J, Hildebrandt J . Cardiorespiratory transients in exercising man. I. Tests of superposition. J Appl Physiol. 1973; 35(1):58-67. DOI: 10.1152/jappl.1973.35.1.58. View

JOSE A, Taylor R . Autonomic blockade by propranolol and atropine to study intrinsic myocardial function in man. J Clin Invest. 1969; 48(11):2019-31. PMC: 297454. DOI: 10.1172/JCI106167. View

Fujihara Y, Hildebrandt J, Hildebrandt J . Cardiorespiratory transients in exercising man. II. Linear models. J Appl Physiol. 1973; 35(1):68-76. DOI: 10.1152/jappl.1973.35.1.68. View

Sato I, Hasegawa Y, Hotta K . System analysis of heart rate control in man. J Appl Physiol. 1976; 41(5 Pt. 1):790-6. DOI: 10.1152/jappl.1976.41.5.790. View

Chamberlain D, Turner P, Sneddon J . Effects of atropine on heart-rate in healthy man. Lancet. 1967; 2(7505):12-5. DOI: 10.1016/s0140-6736(67)90057-8. View

LEVY M . Sympathetic-parasympathetic interactions in the heart. Circ Res. 1971; 29(5):437-45. DOI: 10.1161/01.res.29.5.437. View

Warner H, Cox A . A mathematical model of heart rate control by sympathetic and vagus efferent information. J Appl Physiol. 1962; 17:349-55. DOI: 10.1152/jappl.1962.17.2.349. View

Sutton J, Hughson R, McDonald R, Powles P, Jones N, Fitzgerald J . Oral and intravenous propranolol during exercise. Clin Pharmacol Ther. 1977; 21(6):700-5. DOI: 10.1002/cpt1977216700. View

Chess G, CALARESU F . A mathematical model of the vagus-heart period system in the cat. IEEE Trans Biomed Eng. 1974; 21(1):21-7. DOI: 10.1109/tbme.1974.324357. View

10.

Warner H, Russell Jr R . Effect of combined sympathetic and vagal stimulation on heart rate in the dog. Circ Res. 1969; 24(4):567-73. DOI: 10.1161/01.res.24.4.567. View

11.

Black J, Duncan W, Shanks R . Comparison of some properties of pronethalol and propranolol. Br J Pharmacol Chemother. 1965; 25(3):577-91. PMC: 1510623. DOI: 10.1111/j.1476-5381.1965.tb01782.x. View

12.

Robinson B, Epstein S, Beiser G, Braunwald E . Control of heart rate by the autonomic nervous system. Studies in man on the interrelation between baroreceptor mechanisms and exercise. Circ Res. 1966; 19(2):400-11. DOI: 10.1161/01.res.19.2.400. View

13.

Katona P, Martin P, Jih F . Neural control of heart rate: a conciliation of models. IEEE Trans Biomed Eng. 1976; 23(2):164-6. DOI: 10.1109/tbme.1976.324579. View

14.

Chess G, Varey D, Henry J, CALARESU F . A mathematical model of the sympathetic-heart period system in the cat. Ann Biomed Eng. 1975; 3(2):189-98. DOI: 10.1007/BF02363070. View

15.

Epstein S, Robinson B, Kahler R, Braunwald E . Effects of beta-adrenergic blockade on the cardiac response to maximal and submaximal exercise in man. J Clin Invest. 1965; 44(11):1745-53. PMC: 289674. DOI: 10.1172/JCI105282. View

16.

Ekblom B, Goldbarg A, Kilbom A, Astrand P . Effects of atropine and propranolol on the oxygen transport system during exercise in man. Scand J Clin Lab Invest. 1972; 30(1):35-42. DOI: 10.3109/00365517209081087. View

17.

Braunwald E . Regulation of the circulation. I. N Engl J Med. 1974; 290(20):1124-9. DOI: 10.1056/NEJM197405162902008. View

18.

Wigertz O . Dynamics of respiratory and circulatory adaptation to muscular exercise in man. A systems analysis approach. Acta Physiol Scand Suppl. 1971; 363:1-32. View

19.

JOSE A . Effect of combined sympathetic and parasympathetic blockade on heart rate and cardiac function in man. Am J Cardiol. 1966; 18(3):476-8. DOI: 10.1016/0002-9149(66)90073-7. View

20.

Chess G, CALARESU F . Frequency response model of vagal control of heart rate in the cat. Am J Physiol. 1971; 220(2):554-7. DOI: 10.1152/ajplegacy.1971.220.2.554. View