The Analysis of Malignancy by Cell Fusion

Overview

Journal In Vitro

Specialties Anatomy & Histology
Cell Biology

Date 1980 Jan 1

PMID 7189179

Citations 3

Authors

E Sidebottom

Affiliations

Soon will be listed here.

Abstract

The lecture reviews some aspects of the work on the analysis of malignancy that have been, and are now being, pursured in the Dunn School. A brief outline of the early experiments that first demonstrated that the malignancy of mouse tumor cells can be suppressed by the fusion with normal cells is given, and then two areas of current interest in the laboratory are described. The first is an attempt to analyze the clinically important property of tumors to metastasize and the second is the work on the isolation and identification of an abnormal membrane glycoprotein present in tumor cells. In addition the value of cell fusion methods as a general test of hypotheses of malignancy is emphasized.

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