The Role of Randomization in Clinical Trials

Overview

Journal Stat Med

Publisher Wiley

Specialty Public Health

Date 1982 Oct 1

PMID 7187102

Citations 32

Authors

P Armitage

Affiliations

Soon will be listed here.

Abstract

Random assignment of treatments is an essential feature of experimental design in general and clinical trials in particular. It provides broad comparability of treatment groups and validates the use of statistical methods for the analysis of results. Various devices are available for improving the balance of prognostic factors across treatment groups. Several recent initiatives to diminish the role of randomization are seen as being potentially misleading. Randomization is entirely compatible with medical ethics in circumstances when the treatment of choice is not clearly identified.

Citing Articles

Whole Person Modeling: a transdisciplinary approach to mental health research.

Felsky D, Cannitelli A, Pipitone J Discov Ment Health. 2023; 3(1):16.

PMID: 37638348 PMC: 10449734. DOI: 10.1007/s44192-023-00041-6.

Good Scientific Practice and Ethics in Sports and Exercise Science: A Brief and Comprehensive Hands-on Appraisal for Sports Research.

Arora N, Roehrken G, Crumbach S, Phatak A, Labott B, Nicklas A Sports (Basel). 2023; 11(2).

PMID: 36828332 PMC: 9964730. DOI: 10.3390/sports11020047.

WHO guidance on COVID-19 vaccine trial designs in the context of authorized COVID-19 vaccines and expanding global access: Ethical considerations.

Singh J, Kochhar S, Wolff J, Atuire C, Bhan A, Emanuel E Vaccine. 2022; 40(14):2140-2149.

PMID: 35248422 PMC: 8882397. DOI: 10.1016/j.vaccine.2022.02.038.

Pharmacometrics meets statistics-A synergy for modern drug development.

Ryeznik Y, Sverdlov O, Svensson E, Montepiedra G, Hooker A, Wong W CPT Pharmacometrics Syst Pharmacol. 2021; 10(10):1134-1149.

PMID: 34318621 PMC: 8520751. DOI: 10.1002/psp4.12696.

Applied comparison of large-scale propensity score matching and cardinality matching for causal inference in observational research.

Fortin S, Johnston S, Schuemie M BMC Med Res Methodol. 2021; 21(1):109.

PMID: 34030640 PMC: 8146256. DOI: 10.1186/s12874-021-01282-1.