Murine Models of Metastatic Neoplasia to the Central Nervous System

Overview

Journal Cancer Metastasis Rev

Specialty Oncology

Date 1982 Jan 1

PMID 7185422

Citations 1

Authors

F K Conley

Affiliations

Soon will be listed here.

Abstract

Reliable animal models of metastatic disease to the central nervous system (CNS) are a necessary prerequisite to understanding those mechanisms of development and growth of neoplasia which may be unique to the brain. The ideal model, which should mimic the clinical picture of CNS metastasis in humans, has yet to be developed. Available models contain some degree of artificiality in that they depend upon either arterial inoculation of a tumor cell bolus or intravenous injection of a bolus of cells from a selected tumor cell colony which shows preference for the brain. Applications as well as advantages and disadvantages of the various models are considered.

Citing Articles

B16 melanoma spontaneous brain metastasis: occurrence and development within leptomeninges blood vessels.

Alterman A, Stackpole C Clin Exp Metastasis. 1989; 7(1):15-23.

PMID: 2908827 DOI: 10.1007/BF02057178.

References

Raz A, Hart I . Murine melanoma: a model for intracranial metastasis. Br J Cancer. 1980; 42(2):331-41. PMC: 2010379. DOI: 10.1038/bjc.1980.235. View

Carmel R, Brown J . The effect of cyclophosphamide and other drugs on the incidence of pulmonary metastases in mice. Cancer Res. 1977; 37(1):145-51. View

Brunson K, Beattie G, Nicolsin G . Selection and altered properties of brain-colonising metastatic melanoma. Nature. 1978; 272(5653):543-5. DOI: 10.1038/272543a0. View

HOFFSTEN P, Dixon F . Effect of irradiation and cyclophosphamide on anti-KLH antibody formation in mice. J Immunol. 1974; 112(2):564-72. View

Ballinger Jr W, Schimpff R . An experimental model for cerebral metastasis: preliminary light and ultrastructural studies. J Neuropathol Exp Neurol. 1979; 38(1):19-34. DOI: 10.1097/00005072-197901000-00003. View

Marx J . Tumors; a mixed bag of cells. Science. 1982; 215(4530):275-7. DOI: 10.1126/science.7053575. View

Nicolson G, Custead S . Tumor metastasis is not due to adaptation of cells to a new organ environment. Science. 1982; 215(4529):176-8. DOI: 10.1126/science.7053568. View

Silverberg E . Cancer statistics, 1982. CA Cancer J Clin. 1982; 32(1):15-31. View

Fidler I . Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res. 1978; 38(9):2651-60. View

10.

Conley F . Development of a metastatic brain tumor model in mice. Cancer Res. 1979; 39(3):1001-7. View

11.

Greene H . Heterotransplantation of tumors. Ann N Y Acad Sci. 1957; 69(4):818-29. DOI: 10.1111/j.1749-6632.1957.tb49720.x. View

12.

Nicolson G, Birdwell C, Brunson K, Robbins J, Beattie G, Fidler I . Cell interactions in the metastatic process: some cell surface properties associated with successful blood-borne tumor spread. Soc Gen Physiol Ser. 1977; 32:225-41. View

13.

Kawaguchi T, Nakamura K . Relationship between transcerebral passage of tumor cells and brain metastasis. Gan. 1977; 68(1):65-71. View

14.

Machinami R . A study of the invasive growth of malignant tumors. II. Ultrastructural features of the metastatic growth of Yoshida ascites hepatoma 7974 in the rat brain. Acta Pathol Jpn. 1973; 23(2):261-78. DOI: 10.1111/j.1440-1827.1973.tb00791.x. View

15.

Conley F . Effect of Corynebacterium parvum and chronic Toxoplasma infection on metastatic brain tumors in mice. J Natl Cancer Inst. 1979; 63(5):1237-44. View

16.

Pimm M, Embleton M, Baldwin R . Multiple antigenic specificities within primary 3-methylcholanthrene-induced rat sarcomas and metastases. Int J Cancer. 1980; 25(5):621-9. DOI: 10.1002/ijc.2910250512. View

17.

SCHEINBERG L, Levy A, EDELMAN F . Is the brain an "immunologically privileged site"? 2. Studies in induced host resistance to transplantable mouse glioma following irradiation of prior implants. Arch Neurol. 1965; 13(3):283-6. DOI: 10.1001/archneur.1965.00470030063005. View

18.

Medawar P . Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. Br J Exp Pathol. 1948; 29(1):58-69. PMC: 2073079. View

19.

Fidler I, Hart I . The origin of metastatic heterogeneity in tumors. Eur J Cancer (1965). 1981; 17(5):487-94. DOI: 10.1016/0014-2964(81)90049-9. View

20.

Fidler I . Metastasis: quantitative analysis of distribution and fate of tumor emboli labeled with 125 I-5-iodo-2'-deoxyuridine. J Natl Cancer Inst. 1970; 45(4):773-82. View