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Bronchial Mucous Glands in the Newborn with Cystic Fibrosis

Overview
Journal Eur J Pediatr
Specialty Pediatrics
Date 1982 Dec 1
PMID 7182186
Citations 10
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Abstract

The size of bronchial mucous glands in 21 patients who presented with meconium ileus and died at less than three weeks of age were compared quantitatively with that of 28 control patients. There were no significant differences by most methods of comparison. However, pulmonary infection was seen in a higher percentage of cystic fibrosis patients. The absence of mucous gland hyperplasia at birth suggests that mucous obstruction of airways may not be primarily responsible for the increased susceptibility to respiratory tract infection in cystic fibrosis, but when present later in life may aggravate the infection.

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References
1.
ZUELZER W, NEWTON Jr W . The pathogenesis of fibrocystic disease of the pancreas; a study of 36 cases with special reference to the pulmonary lesions. Pediatrics. 1949; 4(1):53-69. View

2.
Oppenheimer E, ESTERLY J . Cystic fibrosis of the pancreas. Morphologic findings in infants with and without diagnostic pancreatic lesions. Arch Pathol. 1973; 96(3):149-54. View

3.
ESTERLY J, Oppenheimer E . Observations in cystic fibrosis of the pancreas. 3. Pulmonary lesions. Johns Hopkins Med J. 1968; 122(2):94-101. View

4.
Rickham P, BOECKMAN C . NEONATAL MECONIUM OBSTRUCTION IN THE ABSENCE OF MUCOVISCIDOSIS. Am J Surg. 1965; 109:173-7. View

5.
Oppenheimer E, ESTERLY J . Pathology of cystic fibrosis review of the literature and comparison with 146 autopsied cases. Perspect Pediatr Pathol. 1975; 2:241-78. View