Nondisjunction and Chromosome Breakage in Mouse Oocytes After Various X-ray Doses

Overview

Journal Hum Genet

Specialty Genetics

Date 1982 Jan 1

PMID 7173859

Citations 3

Authors

I Hansmann

J Jenderny

H D Probeck

Affiliations

Soon will be listed here.

Abstract

The effect of varying X-ray doses (0.05-0.80 Gy) on preovulatory mouse oocytes was studied by measuring nondisjunction during the first meiotic division, as well as structural chromosome anomalies in ovulated oocytes at metaphase stage II. The incidence of nondisjunction (0.1% hyperploid oocytes) found in oocytes from nonirradiated NMRI-Han female mice was in accordance with the results previously obtained with the same strain. Significantly (P less than 0.05) more hyperploid oocytes (0.9%) were ovulated following irradiation with 0.8 Gy. There was no statistically significant increase of nondisjunction after low doses. Structural chromosome anomalies occurred, however, even after an irradiation dose as low as 0.05 Gy. The dose response for structural chromosome anomalies is altogether different from that of radiation-induced hyperploidy. We consider that irradiation of mature oocytes might well be less hazardous with regard to its potency for increasing nondisjunction during the first meiotic division when compared with the effect of chemical mutagens.

Citing Articles

Decline in the Conception Rate of Wild Japanese Monkeys after the Fukushima Daiichi Nuclear Power Plant Accident.

Hayama S, Nakanishi S, Tanaka A, Kato T, Watanabe C, Kikuchi N Arch Environ Contam Toxicol. 2024; 86(4):325-334.

PMID: 38664243 PMC: 11143026. DOI: 10.1007/s00244-024-01063-z.

Radiobiology and reproduction-what can we learn from Mammalian females?.

Ruiz-Herrera A, Garcia F, Garcia-Caldes M Genes (Basel). 2014; 3(3):521-44.

PMID: 24704983 PMC: 3899996. DOI: 10.3390/genes3030521.

The genetic basis of non-disjunction: increased incidence of hyperploidy in oocytes from F1 hybrid mice.

Hansmann I, Jenderny J Hum Genet. 1983; 65(1):56-60.

PMID: 6642508 DOI: 10.1007/BF00285029.

References

Parker D . Heterologous interchange at meiosis in Drosophila. II. Some disjunctional consequences of interchange. Mutat Res. 1969; 7(3):393-407. DOI: 10.1016/0027-5107(69)90110-9. View

Kamiguchi Y, Mikamo K . Dose-response relationship for induction of structural chromosome aberrations in Chinese hamster oocytes after x-irradiation. Mutat Res. 1982; 103(1):33-7. DOI: 10.1016/0165-7992(82)90083-5. View

ROHRBORN G, Hansmann I . Induced chromosome aberrations in unfertilized oocytes of mice. Humangenetik. 1971; 13(3):184-98. DOI: 10.1007/BF00326941. View

CHANDLEY A, Speed R . Testing for nondisjunction in the mouse. Environ Health Perspect. 1979; 31:123-9. PMC: 1637644. DOI: 10.1289/ehp.7931123. View

Schull W, Otake M, Neel J . Genetic effects of the atomic bombs: a reappraisal. Science. 1981; 213(4513):1220-7. DOI: 10.1126/science.7268429. View

Reichert W, Hansmann I, ROHRBORN G . Chromosome anomalies in mouse oocytes after irradiation. Humangenetik. 1975; 28(1):25-38. DOI: 10.1007/BF00272479. View

Hansmann I, Probeck H . Chromosomal imbalance in ovulated oocytes from Syrian hamsters (Mesocricetus auratus) and Chinese hamsters (Cricetulus griseus). Cytogenet Cell Genet. 1979; 23(1-2):70-6. DOI: 10.1159/000131304. View

TATES A . Microtus oeconomus (Rodentia), a useful mammal for studying the induction of sex-chromosome nondisjunction and diploid gametes in male germ cells. Environ Health Perspect. 1979; 31:151-9. PMC: 1637652. DOI: 10.1289/ehp.7931151. View

Hansmann I, Probeck H . Detection of nondisjunction in mammals. Environ Health Perspect. 1979; 31:161-5. PMC: 1637655. DOI: 10.1289/ehp.7931161. View

10.

Hansmann I, El-Nahass E . Incidence of nondisjunction in mouse oocytes. Cytogenet Cell Genet. 1979; 24(2):115-21. DOI: 10.1159/000131364. View

11.

Strausmanis R, Henrikson I, Holmberg M, Ronnback C . Lack of effect on the chromosomal non-disjunction in aged female mice after low dose X-irradiation. Mutat Res. 1978; 49(2):269-74. DOI: 10.1016/0027-5107(78)90165-3. View

12.

UCHIDA I, Lee C . Radiation-induced nondisjunction in mouse oocytes. Nature. 1974; 250(467):601-2. DOI: 10.1038/250601a0. View

13.

Gosden R, Walters D . Effects of low-dose x-irradiation on chromosomal non-disjunction in aged mice. Nature. 1974; 248(5443):54-5. DOI: 10.1038/248054a0. View

14.

Max C . Cytological investigation of embryos in low-dose X-irradiated young and old female inbred mice. Hereditas. 1977; 85(2):199-206. DOI: 10.1111/j.1601-5223.1977.tb00966.x. View

15.

Speed R, CHANDLEY A . The response of germ cells of the mouse to the induction of non-disjunction by X-rays. Mutat Res. 1981; 84(2):409-18. DOI: 10.1016/0027-5107(81)90208-6. View

16.

SZEMERE G, CHANDLEY A . Trisomy and triploidy induced by X-irradiation of mouse spermatocytes. Mutat Res. 1975; 33(2-3):229-38. DOI: 10.1016/0027-5107(75)90199-2. View

17.

UCHIDA I, FREEMAN C . Radiation-induced nondisjunction in oocytes of aged mice. Nature. 1977; 265(5590):186-7. DOI: 10.1038/265186a0. View

18.

Yamamoto M, Shimada T, Endo A, Watanabe G . Effects of low-dose x irradiation on the chromosomal non-disjunction in aged mice. Nat New Biol. 1973; 244(137):206-8. DOI: 10.1038/newbio244206a0. View

19.

Hansmann I, Zmarsly R, Probeck H, Schafer J, Jenderny J . Aneuploidy in mouse fetuses after paternal exposure to x rays. Nature. 1979; 280(5719):228-9. DOI: 10.1038/280228a0. View