The Normal Anatomy of the Pig Tailed Macaque (Macaca Nemestrina) Outflow Apparatus with Particular Reference to the Presence of Smooth Muscle

Overview

Journal Graefes Arch Clin Exp Ophthalmol

Specialty Ophthalmology

Date 1982 Jan 1

PMID 7160630

Citations 2

Authors

P G McMenamin

W R Lee

Affiliations

Soon will be listed here.

Abstract

The normal anatomy of the pig tailed macaque (Macaca nemestrina) outflow system has until now been undocumented. Tissue from ten monkeys was investigated by light microscopy, transmission electron microscopy and scanning electron microscopy. Although the basic configuration of the outflow apparatus was similar to other subhuman primates it did differ in the following aspects: a) bundles of circumferentially orientated smooth muscle cells were present in the outer and posterior part of the trabecular meshwork near Schlemm's Canal, b) large 'atypical' endothelial cells with microfilament rich cytoplasm were present in the cribriform layer, c) numerous collagenous cords and septae were present in Schlemm's Canal which also appeared to be drained by more than the usual number of collector channels. The possible importance of these anatomical differences is discussed.

Citing Articles

The development of the chamber angle in the rat eye. Morphological characteristics of developmental stages.

Reme C, Urner U, Aeberhard B Graefes Arch Clin Exp Ophthalmol. 1983; 220(3):139-53.

PMID: 6852552 DOI: 10.1007/BF02175946.

Human fetal iridocorneal angle: a light and scanning electron microscopic study.

McMenamin P Br J Ophthalmol. 1989; 73(11):871-9.

PMID: 2605142 PMC: 1041918. DOI: 10.1136/bjo.73.11.871.

References

Lee W, Grierson I . Relationships between intraocular pressure and the morphology of the outflow apparatus. Trans Ophthalmol Soc U K (1962). 1974; 94(2):430-49. View

Knepper P, Farbman A, BONDAREFF W . A smooth muscle plexus associated with the aqueous outflow pathway of the rabbit eye. Anat Rec. 1975; 182(1):41-51. DOI: 10.1002/ar.1091820105. View

Tsukahara S . The existence of smooth muscle adjacent to the Schlemm's canal of the normal albino rat eye. Acta Ophthalmol (Copenh). 1978; 56(5):735-41. DOI: 10.1111/j.1755-3768.1978.tb06637.x. View

Tripathi R . The functional morphology of the outflow systems of ocular and cerebrospinal fluids. Exp Eye Res. 1977; 25 Suppl:65-116. DOI: 10.1016/s0014-4835(77)80010-9. View

Grierson I, Rahi A . Microfilaments in the cells of the human trabecular meshwork. Br J Ophthalmol. 1979; 63(1):3-8. PMC: 1043377. DOI: 10.1136/bjo.63.1.3. View

Grierson I, Lee W, Abraham S . Effects of pilocarpine on the morphology of the human outflow apparatus. Br J Ophthalmol. 1978; 62(5):302-13. PMC: 1043218. DOI: 10.1136/bjo.62.5.302. View

Raviola G . Schwalbe line's cells: a new cell type in the trabecular meshwork of Macaca mulatta. Invest Ophthalmol Vis Sci. 1982; 22(1):45-56. View

Rohen J, Lutjen E, BARANY E . The relation between the ciliary muscle and the trabecular meshwork and its importance for the effect of miotics on aqueous outflow resistance. A study in two contrasting monkey species, Macaca irus and Cercopithecus aethiops. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1967; 172(1):23-47. DOI: 10.1007/BF00577152. View

Grierson I, Lee W, Abraham S . The effects of topical pilocarpine on the morphology of the outflow apparatus of the baboon (Papio cynocephalus). Invest Ophthalmol Vis Sci. 1979; 18(4):346-55. View

10.

McMenamin P, Lee W . Age related changes in extracellular materials in the inner wall of Schlemm's canal. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980; 212(3-4):159-72. DOI: 10.1007/BF00410512. View

11.

Grierson I, Lee W . Changes in the monkey outflow apparatus at graded levels of intraocular pressure: a qualitative analysis by light microscopy and scanning electron microscopy. Exp Eye Res. 1974; 19(1):21-33. DOI: 10.1016/0014-4835(74)90068-2. View

12.

Grierson I, Lee W, Abraham S . A light microscopic study of the effects of testicular hyaluronidase on the outflow system of a baboon (Papio cynocephalus). Invest Ophthalmol Vis Sci. 1979; 18(4):356-60. View

13.

Ringvold A . Actin filaments in trabecular endothelial cells in eyes of the vervet monkey. (Cercopithecus aethiops). Acta Ophthalmol (Copenh). 1978; 56(2):217-25. DOI: 10.1111/j.1755-3768.1978.tb01347.x. View

14.

Rahi A, Grierson I, Ashton N . Contractile proteins in ocular tissues. Their role in health and disease. Trans Ophthalmol Soc U K (1962). 1980; 100(Pt 1):155-61. View

15.

JOHNSTONE M, GRANT W . Pressure-dependent changes in structures of the aqueous outflow system of human and monkey eyes. Am J Ophthalmol. 1973; 75(3):365-83. DOI: 10.1016/0002-9394(73)91145-8. View

16.

Moses R, Grodzki Jr W, Etheridge E, Wilson C . Schlemm's canal: the effect of intraocular pressure. Invest Ophthalmol Vis Sci. 1981; 20(1):61-8. View

17.

Moses R . Circumferential flow in Schlemm's canal. Am J Ophthalmol. 1979; 88(3 Pt 2):585-91. DOI: 10.1016/0002-9394(79)90519-1. View

18.

Gipson I, Anderson R . Actin filaments in cells of human trabecular meshwork and Schlemm's canal. Invest Ophthalmol Vis Sci. 1979; 18(6):547-61. View

19.

KAYES J . Pressure gradient changes on the trabecular meshwork of monkeys. Am J Ophthalmol. 1975; 79(4):549-56. DOI: 10.1016/0002-9394(75)90791-6. View