Characterization of a Nonvirulent Variant of Lymphocytic Choriomeningitis Virus

Overview

Journal Arch Virol

Specialty Microbiology

Date 1982 Jan 1

PMID 7159222

Authors

P R Brayton

H F Maassab

Affiliations

Soon will be listed here.

Abstract

A cold-adapted, nonvirulent variant of the Armstrong strain of lymphocytic choriomeningitis virus was isolated from infected L929 cells maintained at 25 degrees C. This variant, designated P17, was capable of replicating in the central nervous system of mice without causing disease and conferring immunity to back challenge with the parental strain.

References

Lehmann-Grube F, Slenczka W, Tees R . A persistent and inapparent infection of L cells with the virus of lymphocytic choriomeningitis. J Gen Virol. 1969; 5(1):63-81. DOI: 10.1099/0022-1317-5-1-63. View

Bishop D, Beaty B, Shope R . Recombination and gene coding assignments of bunyaviruses and arenaviruses. Ann N Y Acad Sci. 1980; 354:84-106. DOI: 10.1111/j.1749-6632.1980.tb27960.x. View

KIRK W, Cash P, Peters C, Bishop D . Formation and characterization of an intertypic lymphocytic choriomeningitis recombinant virus. J Gen Virol. 1980; 51(Pt 1):213-8. DOI: 10.1099/0022-1317-51-1-213. View

Kent J, FIFE Jr E . Precise standardization of reagents for complement fixation. Am J Trop Med Hyg. 1963; 12:103-16. DOI: 10.4269/ajtmh.1963.12.103. View

Rowe W, Murphy F, BERGOLD G, Casals J, HOTCHIN J, Johnson K . Arenoviruses: proposed name for a newly defined virus group. J Virol. 1970; 5(5):651-2. PMC: 376052. DOI: 10.1128/JVI.5.5.651-652.1970. View

Jacobson S, Friedman R, Pfau C . Interferon induction by lymphocytic choriomeningitis viruses correlates with maximum virulence. J Gen Virol. 1981; 57(Pt 2):275-83. DOI: 10.1099/0022-1317-57-2-275. View

HOTCHIN J, Kinch W, Benson L, Sikora E . Role of substrains in persistent lymphocytic choriomeningitis virus infection. Bull World Health Organ. 1975; 52(4-6):457-63. PMC: 2366667. View

Popescu M, Lehmann-Grube F . Defective interfering particles in mice infected with lymphocytic choriomeningitis virus. Virology. 1977; 77(1):78-83. DOI: 10.1016/0042-6822(77)90407-x. View

Kimmig B, Lehmann-Grube F . The immune response of the mouse to lymphocytic choriomeningitis virus. I. Circulating antibodies. J Gen Virol. 1979; 45(3):703-10. DOI: 10.1099/0022-1317-45-3-703. View

10.

HOTCHIN J, Kinch W, Benson L . Lytic and turbid plaque-type mutants of lymphocytic choriomeningitis virus as a cause of neurological disease or persistent infection. Infect Immun. 1971; 4(3):281-6. PMC: 416301. DOI: 10.1128/iai.4.3.281-286.1971. View

11.

Popescu M, Lehmann-Grube F . Diversity of lymphocytic choriomeningitis virus: variation due to replication of the virus in the mouse. J Gen Virol. 1976; 30(1):113-22. DOI: 10.1099/0022-1317-30-1-113. View

12.

Cihak J, Lehmann-Grube F . Persistent infection of mice with the virus of lymphocytic choriomeningitis: virus-specific immunological tolerance. Infect Immun. 1974; 10(5):1072-6. PMC: 423064. DOI: 10.1128/iai.10.5.1072-1076.1974. View

13.

Dutko F, Pfau C . Arenavirus defective interfering particles mask the cell-killing potential of standard virus. J Gen Virol. 1978; 38(2):195-208. DOI: 10.1099/0022-1317-38-2-195. View

14.

Suzuki S, HOTCHIN J . Initiation of persistent lymphocytic choriomeningitis infection in adult mice. J Infect Dis. 1971; 123(6):603-10. DOI: 10.1093/infdis/123.6.603. View

15.

GRESSER I, Bourali C, Thomas M . A comparison of the efficacy of endogenous, exogenous, and combined endogenous-exogenous interferon in the treatment of mice infected with encephalomyocarditis virus. Proc Soc Exp Biol Med. 1969; 130(1):236-42. DOI: 10.3181/00379727-130-33529. View

16.

Jacobson S, Dutko F, Pfau C . Determinants of spontaneous recovery and persistance in MDCK cells infected with lymphocytic choriomeningitis virus. J Gen Virol. 1979; 44(1):113-22. DOI: 10.1099/0022-1317-44-1-113. View

17.

Welsh R, Pfau C . Determinants of lymphocytic choriomeningitis interference. J Gen Virol. 1972; 14(2):177-87. DOI: 10.1099/0022-1317-14-2-177. View

18.

Riviere Y, GRESSER I, GUILLON J, Bandu M, Ronco P, MOREL-MAROGER L . Severity of lymphocytic choriomeningitis virus disease in different strains of suckling mice correlates with increasing amounts of endogenous interferon. J Exp Med. 1980; 152(3):633-40. PMC: 2185917. DOI: 10.1084/jem.152.3.633. View