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Early Effects of Intravenous Terbutaline on Cardiopulmonary Function in Chronic Obstructive Bronchitis and Pulmonary Hypertension

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Journal Thorax
Date 1982 Oct 1
PMID 7157213
Citations 3
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Abstract

Terbutaline sulphate (0.25 mg) was given intravenously to 10 recumbent patients with severe irreversible airflow obstruction and pulmonary hypertension who were undergoing right heart catheterisation. Alveolar ventilation index, cardiac index, and mean pulmonary artery pressure all rose significantly at 5 minutes and then fell by 35 minutes, although the first two remained higher than control levels. This was accompanied by a small but significant rise in arterial oxygen tension at 5 minutes. There were no significant changes in ventilation-perfusion relationships at either 5 or 35 minutes.

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References
1.
KNUDSON R, CONSTANTINE H . An effect of isoproterenol on ventilation-perfusion in asthmatic versus normal subjects. J Appl Physiol. 1967; 22(3):402-6. DOI: 10.1152/jappl.1967.22.3.402. View

2.
Harris P, SEGEL N, Bishop J . The relation between pressure and flow in the pulmonary circulation in normal subjects and in patients with chronic bronchitis and mitral stenosis. Cardiovasc Res. 1968; 2(1):73-83. DOI: 10.1093/cvr/2.1.73. View

3.
HARRIS L . Effects of isoprenaline plus phenylephrine by pressurized aerosol on blood gases, ventilation, and perfusion in chronic obstructive lung disease. Br Med J. 1970; 4(5735):579-82. PMC: 1820193. DOI: 10.1136/bmj.4.5735.579. View

4.
ARNER B, BERTLER A, KARLEFORS T, WESTLING H . Circulatory effects of orciprenaline, adrenaline and a new sympathomimetic beta-receptor-stimulating agent, terbutaline, in normal human subjects. Acta Med Scand Suppl. 1970; 512:25-32. DOI: 10.1111/j.0954-6820.1970.tb05286.x. View

5.
Harris L . Comparison of the effect on blood gases, ventilation, and perfusion of isoproterenol-phenylephrine and salbutamol aerosols in chronic bronchitis with asthma. J Allergy Clin Immunol. 1972; 49(2):63-71. DOI: 10.1016/0091-6749(72)90057-7. View