Role of Dopamine Receptors in the Modulation of Acetylcholine Release in the Rabbit Hippocampus

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1982 Dec 1

PMID 7155199

Citations 8

Authors

H Strittmatter

R Jackisch

G Hertting

Affiliations

Soon will be listed here.

Abstract

Modulation of acetylcholine release was studied in slices of the rabbit hippocampus preincubated with 3H-choline and then continuously superfused with a medium containing 10 mumol/l hemicholinium-3. Electrical field stimulation of the superfused slices elicited an increase in tritium outflow, which was tetrodotoxin-sensitive and largely calcium-dependent. Stimulus-evoked acetylcholine release in the rabbit hippocampal slices was modulated by presynaptic muscarinic autoreceptors, as has been shown previously for the rat hippocampus. Drugs with affinity for alpha- and or beta-adrenoceptors did not affect the evoked overflow of tritium from rabbit hippocampal slices. In contrast, the dopamine receptor agonist apomorphine (0.1 or 1 mumol/l) and exogenous dopamine (1 or 10 mumol/l) significantly reduced the evoked outflow by about 10 or 20%, respectively. This effect was antagonized by haloperidol (0.01 mumol/l) but not by phentolamine (1 mumol/l). Attempts to enhance (using nomifensine 10 mumol/l) or reduce (using haloperidol, up to 1 mumol/l; or bretylium, 1 mmol/l for 5 min) endogenous dopaminergic transmission in the hippocampal slices did not affect stimulation evoked acetylcholine release. In conclusion, presynaptic dopamine receptors modulating acetylcholine release are present in the rabbit hippocampus, but they seem not to be of physiological significance.

Citing Articles

Characterization of muscarinic autoreceptors in the rabbit hippocampus and caudate nucleus.

Stoll C, Schwarzwalder U, Johann S, Lambrecht G, Hertting G, Feuerstein T Neurochem Res. 2003; 28(3-4):413-7.

PMID: 12675124 DOI: 10.1023/a:1022836315383.

Endogenous adenosine as a modulator of hippocampal acetylcholine release.

Jackisch R, Strittmatter H, Kasakov L, Hertting G Naunyn Schmiedebergs Arch Pharmacol. 1984; 327(4):319-25.

PMID: 6083455 DOI: 10.1007/BF00506243.

False labelling of dopaminergic terminals in the rabbit caudate nucleus: uptake and release of [3H]-5-hydroxytryptamine.

Feuerstein T, Hertting G, Lupp A, Neufang B Br J Pharmacol. 1986; 88(3):677-84.

PMID: 3742155 PMC: 1916973. DOI: 10.1111/j.1476-5381.1986.tb10250.x.

Protein kinase C and presynaptic modulation of acetylcholine release in rabbit hippocampus.

Allgaier C, Daschmann B, Huang H, Hertting G Br J Pharmacol. 1988; 93(3):525-34.

PMID: 3370387 PMC: 1853841. DOI: 10.1111/j.1476-5381.1988.tb10307.x.

Islet-activating protein (pertussis toxin) diminishes alpha 2-adrenoceptor mediated effects on noradrenaline release.

Allgaier C, Feuerstein T, Jackisch R, Hertting G Naunyn Schmiedebergs Arch Pharmacol. 1985; 331(2-3):235-9.

PMID: 3003591 DOI: 10.1007/BF00634243.

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