Critical Analysis of Granulocyte Function in 154 Patients Wtih Different Diseases

Overview

Journal Klin Wochenschr

Specialty General Medicine

Date 1982 Oct 15

PMID 7144064

Authors

B Bultmann

A Wildfeuer

U Schindlbeck

E Kleihauer

H Heimpel

H J WIGGER

O HAFERKAMP

Affiliations

Soon will be listed here.

Abstract

Several granulocyte functions were analyzed in vitro in 154 patients with chronic or recurrent infections, as well as in a variety of disorders known or suspected to affect host resistance. Only a few specific abnormalities were diagnostic and occurred in congenital, hereditary disorders. Opposed to these permanent changes are those which were probably acquired or transient and are often multifactorial in origin. In the majority of these patients, an inconstant and nonspecific pattern emerged which is not helpful in the diagnosis of underlying disease. In selected patients, however, and as research procedures, these and related tests should be helpful in elucidating the basic functions of granulocytes and may implicate therapeutical approaches.

References

Niethammer D, Wildfeuer A, Kleihauer E, Haferkamp C . [Granulocyte dysfunction. I. Inborn defects (author's transl)]. Klin Wochenschr. 1975; 53(14):643-52. DOI: 10.1007/BF01469293. View

Niethammer D, Heinze E, TELLER W, Kleihauer E, Wildfeuer A, HAFERKAMP O . Impairment of granulocyte function in juvenile diabetes. Klin Wochenschr. 1975; 53(22):1057-60. DOI: 10.1007/BF01614381. View

Bultmann B, Eggers H, HAFERKAMP O . Selective inhibition of human neutrophil chemotaxis by ECHO-virus, type 9. Klin Wochenschr. 1981; 59(11):571-3. DOI: 10.1007/BF01716459. View

SAUNDERS S, DOWDLE E, Fiskerstrand C, Bassendine M, Walls R . Serum factor affecting neutrophil function during acute viral hepatitis. Gut. 1978; 19(10):930-4. PMC: 1412347. DOI: 10.1136/gut.19.10.930. View

Seger R, Wildfeuer A, Buchinger G, ROMEN W, Catty D, Dybas L . Defects in granulocyte function in various chromosome abnormalities (Down's-, Edwards'-, Cri-du-chat syndrome). Klin Wochenschr. 1976; 54(4):177-83. DOI: 10.1007/BF01468883. View

Oliver J . Cell biology of leukocyte abnormalities--membrane and cytoskeletal function in normal and defective cells. A review. Am J Pathol. 1978; 93(1):221-70. PMC: 2018335. View

Valone F . Modulation of human neutrophil and eosinophil polymorphonuclear leukocyte chemotaxis: an analytical review. Clin Immunol Immunopathol. 1980; 15(1):52-65. DOI: 10.1016/0090-1229(80)90020-3. View

Christou N, Meakins J . Neutrophil function in surgical patients: two inhibitors of granulocyte chemotaxis associated with sepsis. J Surg Res. 1979; 26(4):355-64. DOI: 10.1016/0022-4804(79)90020-9. View

Strauss R, Connett J, Gale R, Bloomfield C, Herzig G, McCullough J . A controlled trial of prophylactic granulocyte transfusions during initial induction chemotherapy for acute myelogenous leukemia. N Engl J Med. 1981; 305(11):597-603. DOI: 10.1056/NEJM198109103051101. View

10.

Higby D . Granulocyte transfusions: where now?. N Engl J Med. 1981; 305(11):636-8. DOI: 10.1056/NEJM198109103051109. View

11.

Hill H, Quie P . Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections. Lancet. 1974; 1(7850):183-7. DOI: 10.1016/s0140-6736(74)92493-3. View

12.

Kramer N, Perez H, Goldstein I . An immunoglobulin (IgG) inhibitor of polymorphonuclear leukocyte motility in a patient with recurrent infection. N Engl J Med. 1980; 303(22):1253-8. DOI: 10.1056/NEJM198011273032202. View

13.

Hass R, Niethammer D, Flad H, Wildfeuer A, Bultmann B, HAFERKAMP O . A case of impaired chemotaxis and lymphocyte transformation. Acta Paediatr Scand. 1976; 65(2):241-7. DOI: 10.1111/j.1651-2227.1976.tb16544.x. View

14.

Mowat A, Baum J . Chemotaxis of polymorphonuclear leukocytes from patients with rheumatoid arthritis. J Clin Invest. 1971; 50(12):2541-9. PMC: 292203. DOI: 10.1172/JCI106754. View

15.

Zubler R, Nydegger U, Perrin L, Fehr K, McCormick J, Lambert P . Circulating and intra-articular immune complexes in patients with rheumatoid arthritis. Correlation of 125I-Clq binding activity with clinical and biological features of the disease. J Clin Invest. 1976; 57(5):1308-19. PMC: 436784. DOI: 10.1172/JCI108399. View

16.

Theofilopoulos A, Wilson C, Dixon F . The Raji cell radioimmune assay for detecting immune complexes in human sera. J Clin Invest. 1976; 57(1):169-82. PMC: 436637. DOI: 10.1172/JCI108257. View

17.

Preisig E, HITZIG W . Nitroblue-tetrazolium test for the detection of chronic granulomatous disease--technical modification. Eur J Clin Invest. 1971; 1(6):409-12. DOI: 10.1111/j.1365-2362.1971.tb00550.x. View

18.

Pflieger H, Arnold R, Bhaduri S, Bultmann B, Goldmann S, Haghou F . Beneficial effect of granulocyte transfusions in patients with defects in granulocyte function and severe infections. Scand J Haematol. 1979; 22(1):33-41. DOI: 10.1111/j.1600-0609.1979.tb00397.x. View

19.

Niethammer D, Wildfeuer A, Kleihauer E, HAFERKAMP O . [Granulocyte dysfunction. Part II. Secondary defects. (authors transl)]. Klin Wochenschr. 1975; 53(16):739-46. DOI: 10.1007/BF01614854. View

20.

Mandell G, Hook E . Leukocyte function in chronic granulomatous disease of childhood. Studies on a seventeen year old boy. Am J Med. 1969; 47(3):473-86. DOI: 10.1016/0002-9343(69)90231-9. View