Effect of Partial Cystectomy on the Induction of Pre-neoplastic Lesions in Rat Bladder Initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine Followed by Bladder Carcinogens and Promoters

Overview

Journal Urol Res

Specialty Urology

Date 1982 Jan 1

PMID 7135697

Citations 3

Authors

S Fukushima

M Hirose

M Okuda

J Nakanowatari

A Hatano

N Ito

Affiliations

Soon will be listed here.

Abstract

The effect of partial cystectomy on the occurrence of pre-neoplastic lesions, papillary or nodular hyperplasia (PN hyperplasia), of the bladder in male F344 rats was studied in an experiment in which bladder carcinogens and promoters were given to the rats after initiation with BBN. The bladder carcinogens tested were N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) and N-4[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and the bladder promoters were sodium saccharin, sodium cyclamate, and DL-tryptophan. Partial cystectomy significantly decreased the occurrence of PN hyperplasia in rats treated with EHBN and tended to inhibit that in rats given saccharin or tryptophan. Thus partial cystectomy inhibited rather than enhanced the induction of PN hyperplasia.

Citing Articles

Inhibitory effect of partial cystectomy on experimental carcinogenesis in the urinary bladder.

Kunze E, Woltjen H, Niemann U J Cancer Res Clin Oncol. 1983; 106(2):123-9.

PMID: 6630282 DOI: 10.1007/BF00395390.

Modification of N-methyl-N-nitrosourea-induced urinary bladder carcinogenesis in rats following stimulation of urothelial proliferation by a partial cystectomy.

Kunze E, Gassner G J Cancer Res Clin Oncol. 1986; 112(1):11-8.

PMID: 3733862 DOI: 10.1007/BF00394932.

Timing effects of uracil-induced urolithiasis on amplification of second-stage promotion in rat bladder carcinogenesis.

Shibata M, Hasegawa R, Sano M, Shirai T, Fukushima S Jpn J Cancer Res. 1991; 82(10):1077-84.

PMID: 1659569 PMC: 5918247. DOI: 10.1111/j.1349-7006.1991.tb01760.x.

References

Shirai T, Cohen S, Fukushima S, Hananouchi M, Ito N . Reversible papillary hyperplasia of the rat urinary bladder. Am J Pathol. 1978; 91(1):33-48. PMC: 2018165. View

HERBERTSON B, Steele P, Allen J . DNA synthesis in the urinary tract epithelium of the rat induced by ureteric ligation. Lab Invest. 1981; 45(3):285-94. View

Tatematsu M, Nakanishi K, Murasaki G, Miyata Y, Hirose M, Ito N . Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats. J Natl Cancer Inst. 1979; 63(6):1411-6. View

Fukushima S, Murasaki G, Hirose M, Nakanishi K, Hasegawa R, Ito N . Histopathological analysis of preneoplastic changes during N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder carcinogenesis in rats. Acta Pathol Jpn. 1982; 32(2):243-50. DOI: 10.1111/j.1440-1827.1982.tb02045.x. View

Hashimoto Y, Iiyoshi M, Okada M . Rapid and selective induction of urinary bladder cancer in rats with N-ethyl-N-(4-hydroxybutyl)nitrosoamine and by its principal urinary metabolite. Gan. 1974; 65(6):565-6. View

Ito N, Makiura S, Yokota Y, Kamamoto Y, Hiasa Y . Effect of unilateral ureter ligation on development of tumors in the urinary system of rats treated with N-butyl-N-(4-hydroxybutyl)nitrosoamine. Gan. 1971; 62(5):359-65. View

Hicks R, Wakefield J, Chowaniec J . Evaluation of a new model to detect bladder carcinogens or co-carcinogens; results obtained with saccharin, cyclamate and cyclophosphamide. Chem Biol Interact. 1975; 11(3):225-33. DOI: 10.1016/0009-2797(75)90101-5. View

Nakanishi K, Hirose M, Ogiso T, Hasegawa R, Arai M, Ito N . Effects of sodium saccharin and caffeine on the urinary bladder of rats treated with n-butyl-n-(4-hydroxybutyl)nitrosamine. Gan. 1980; 71(4):490-500. View

Fukushima S, Hananouchi M, Shirai T, Tatematsu M, Hirose M . Effect of plastic bead on gastric carcinogenesis in rats treated with N-methyl-N'-nitro-N-nitrosoguanidine. Gan. 1976; 67(2):197-205. View

10.

Erturk E, Cohen S, Price J, Bryan G . Pathogenesis, histology, and transplantability of urinary bladder carcinomas induced in albino rats by oral administration of N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide. Cancer Res. 1969; 29(12):2219-28. View

11.

BERENBLUM I, SHUBIK P . The role of croton oil applications, associated with a single painting of a carcinogen, in tumour induction of the mouse's skin. Br J Cancer. 1947; 1(4):379-82. PMC: 2007538. DOI: 10.1038/bjc.1947.35. View

12.

Ito N, Tatematsu M, Nakanishi K, Hasegawa R, Takano T, Imaida K . The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide. Gan. 1980; 71(6):832-42. View

13.

Fukushima S, Arai M, Cohen S, Jacobs J, FRIEDELL G . Scanning electron microscopy of cyclophosphamide-induced hyperplasia of the rat urinary bladder. Lab Invest. 1981; 44(2):89-96. View

14.

Narisawa T, Magadia N, WEISBURGER J, Wynder E . Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine in rats. J Natl Cancer Inst. 1974; 53(4):1093-7. DOI: 10.1093/jnci/53.4.1093. View

15.

Cohen S, Arai M, Jacobs J, FRIEDELL G . Promoting effect of saccharin and DL-tryptophan in urinary bladder carcinogenesis. Cancer Res. 1979; 39(4):1207-17. View

16.

Fukushima S, Cohen S, Arai M, Jacobs J, FRIEDELL G . Scanning electron microscopic examination of reversible hyperplasia of the rat urinary bladder. Am J Pathol. 1981; 102(3):373-80. PMC: 1903725. View

17.

Cohen S, Jacobs J, Arai M, Johansson S, FRIEDELL G . Early lesions in experimental bladder cancer: experimental design and light microscopic findings. Cancer Res. 1976; 36(7 PT 2):2508-11. View

18.

Fukushima S, FRIEDELL G, Jacobs J, Cohen S . Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. Cancer Res. 1981; 41(8):3100-3. View

19.

Ito N, Hiasa Y, Tamai A, Okajima E, Kitamura H . Histogenesis of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats. Gan. 1969; 60(4):401-10. View

20.

Tatematsu M, Imaida K, Fukushima S, Arai M, Mizutani M, Ito N . Cytopathological effect of partial cystectomy of rats. Acta Pathol Jpn. 1981; 31(4):535-43. DOI: 10.1111/j.1440-1827.1981.tb02751.x. View