Prazosin in the Diagnosis and Treatment of Pheochromocytoma

Overview

Journal JAMA

Publisher American Medical Association

Specialty General Medicine

Date 1978 Dec 15

PMID 713011

Citations 12

Authors

J M Wallace

D P Gill

Affiliations

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Abstract

In a patient with paraganglioma, severe hypertension due to high levels of plasma norepinephrine was easily controlled with prazosin hydrochloride, 6 to 8 mg/day for 19 days before surgery. A prolonged antihypertensive response to the first two 1-mg doses suggested the presence of pheochromocytoma. This experience dramatizes the remarkable effectiveness of prazosin as a postsynaptic alpha-adrenergic receptor blocker and invites further trials of the drug for both the diagnosis and treatment of pheochromocytoma.

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