Liberation of Serotonin from Rabbit Blood Platelets by Bacterial Cell Walls and Related Compounds

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1982 Sep 1

PMID 7129634

Citations 7

Authors

K Harada

S Kotani

H Takada

M Tsujimoto

Y Hirachi

S Kusumoto

T Shiba

S Kawata

K Yokogawa

H Nishimura

T Kitaura

T Nakajima

Affiliations

Soon will be listed here.

Abstract

A study was made on the activity of various bacterial cell walls and peptidoglycans to liberate serotonin from rabbit blood platelets. All of the test cell walls or peptidoglycans prepared from 27 strains of 21 bacterial species were shown to cause a marked release of serotonin, regardless of differences in types of peptidoglycan and non-peptidoglycan moieties and in some biological properties. The assay made with the water-soluble "digests" of Staphylococcus epidermidis cell wall peptidoglycans, which were prepared by use of appropriate enzymes, revealed that a polymer of peptidoglycan subunits (a disaccharide-stempeptide) was definitely active in the release of serotonin, but a structural unit monomer was inactive. Among a variety of synthetic muramylpeptides and their 6-O-acyl derivatives, only 6-O-(3-hydroxy-2-docosylhexacosanoyl)-N-acetylmuramyl-L-alanyl-D-isoglutaminyl- L-lysyl-D-alanine was found to hold a strong serotonin-liberating activity.

Citing Articles

Some cellular and pathophysiological correlates of the inflammatory effects of a synthetic immunomodulatory agent, muramyl dipeptide (MDP).

Zidek Z, Frankova D, Masek K Agents Actions. 1993; 38(1-2):106-15.

PMID: 8386899 DOI: 10.1007/BF02027221.

Stimulation of migration of human monocytes by bacterial cell walls and muramyl peptides.

Ogawa T, Kotani S, Fukuda K, Tsukamoto Y, Mori M, Kusumoto S Infect Immun. 1982; 38(3):817-24.

PMID: 7152675 PMC: 347821. DOI: 10.1128/iai.38.3.817-824.1982.

Enhancement of dengue virus type 2 replication in mouse macrophage cultures by bacterial cell walls, peptidoglycans, and a polymer of peptidoglycan subunits.

Hotta H, Hotta S, Takada H, Kotani S, Tanaka S, Ohki M Infect Immun. 1983; 41(2):462-9.

PMID: 6874066 PMC: 264663. DOI: 10.1128/iai.41.2.462-469.1983.

Analgesic effects of N-acetylmuramyl-L-alanyl-D-isoglutamine in decreasing the acetic acid-induced abdominal-writhing response.

Ogawa T, Kotani S Infect Immun. 1987; 55(2):494-6.

PMID: 3804449 PMC: 260358. DOI: 10.1128/iai.55.2.494-496.1987.

Structural requirements of muramylpeptides for induction of necrosis at sites primed with Mycobacterium tuberculosis in guinea pigs.

Nagao S, Takada H, YAGAWA K, Kutsukake H, Shiba T, Kusumoto S Infect Immun. 1987; 55(5):1279-88.

PMID: 3106217 PMC: 260502. DOI: 10.1128/iai.55.5.1279-1288.1987.

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