The Effects of Salbutamol, Theophylline and FPL55712 on Leukotriene Contraction of Guinea Pig Trachea

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1982 Aug 27

PMID 7128689

Citations 4

Authors

C L Armour

I J Nicholls

R R Schellenberg

Affiliations

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Abstract

Contraction of guinea pig tracheal smooth muscle was induced by leukotriene C4 or leukotriene D4. The inhibition of the smooth muscle contraction by salbutamol and theophylline was compared with the inhibition by FPL 55712. Salbutamol (5 X 10(-8) - 5 X 10(-7) M) significantly inhibited the leukotriene-induced contraction. The degree of inhibition was greater than that observed with FPL55712 (10(-6) - 10(-4) M). Theophylline (10(-6) - 10(-4) M) did not affect the leukotriene-induced contraction, but enhanced the effect of salbutamol when these agents were combined.

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