Article: Long-term outcome in Felty's syndrome

Felty's syndrome has again been shown to be a severe form of systemic rheumatoid disease characterised by severe joint involvement, many extra-articular features, and a high incidence of infection. In addition we have shown that splenectomy was not protective for infections and in fact may on occasion contributed to infection. Furthermore, although most patients had an increase in white blood cell count after splenectomy, 50% of patients without splenectomy showed a similar increase in white blood cell counts at follow-up. Mortality in Felty's syndrome was high, with infection being the main cause of death.

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References

1.

Ruderman M, Miller L, Pinals R . Clinical and serologic observations on 27 patients with Felty's syndrome. Arthritis Rheum. 1968; 11(3):377-84. DOI: 10.1002/art.1780110302. View

2.

Barnes C, Turnbull A, Vernon-Roberts B . Felty's syndrome. A clinical and pathological survey of 21 patients and their response to treatment. Ann Rheum Dis. 1971; 30(4):359-74. PMC: 1005794. DOI: 10.1136/ard.30.4.359. View

3.

Moore R, Brunner C, SANDUSKY W, Leavell B . Felty's syndrome: long-term follow-up after splenectomy. Ann Intern Med. 1971; 75(3):381-5. DOI: 10.7326/0003-4819-75-3-381. View

4.

Bishop C, ROTHSTEIN G, Ashenbrucker H, Athens J . Leukokinetic studies. XIV. Blood neutrophil kinetics in chronic, steady-state neutropenia. J Clin Invest. 1971; 50(8):1678-89. PMC: 442068. DOI: 10.1172/JCI106657. View

5.

Gordon D, Stein J, BRODER I . The extra-articular features of rheumatoid arthritis. A systematic analysis of 127 cases. Am J Med. 1973; 54(4):445-52. DOI: 10.1016/0002-9343(73)90040-5. View

6.

Zivkovic M, Baum J . Chemotaxis of polymorphonuclear leukocytes from patients with systemic lupus erythematosus and Felty's syndrome. Immunol Commun. 1972; 1(1):39-49. DOI: 10.3109/08820137209022891. View

7.

Vincent P, LEVI J, MacQueen A . The mechanism of neutropenia in Felty's syndrome. Br J Haematol. 1974; 27(3):463-75. DOI: 10.1111/j.1365-2141.1974.tb06812.x. View

8.

Luthra H, Hunder G . Spontaneous remission of Felty's syndrome. Arthritis Rheum. 1975; 18(5):515-7. DOI: 10.1002/art.1780180516. View

9.

Logue G . Felty's syndrome: granulocyte-bound immunoglobulin G and splenectomy. Ann Intern Med. 1976; 85(4):437-42. DOI: 10.7326/0003-4819-85-4-437. View

10.

Spivak J . Felty's syndrome: an analytical review. Johns Hopkins Med J. 1977; 141(3):156-62. View

11.

Sienknecht C, Urowitz M, Pruzanski W, Stein H . Felty's syndrome. Clinical and serological analysis of 34 cases. Ann Rheum Dis. 1977; 36(6):500-7. PMC: 1000154. DOI: 10.1136/ard.36.6.500. View

12.

Goldberg J, Pinals R . Felty syndrome. Semin Arthritis Rheum. 1980; 10(1):52-65. DOI: 10.1016/0049-0172(80)90014-1. View

13.

Wright C, DOAN C, BOURONCLE B, ZOLLINGER R . Direct splenic arterial and venous blood studies in the hypersplenic syndromes before and after epinephrine. Blood. 1951; 6(3):195-212. View

Long-term Outcome in Felty's Syndrome