Pathogenesis of Four-layered Microgyric Cortex in Man

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1982 Jan 1

PMID 7124351

Citations 16

Authors

M C McBride

T L Kemper

Affiliations

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Abstract

Microgyria (polygria, polymicrogyria) has stimulated continued interest since its first description by Meschede [28]. Based on analysis of case material, available staining techniques, and known principles of human cortical development, subsequent investigators have proposed numerous theories to explain its pathogenesis. We have studied a case which cannot be fully explained by these previously proposed theories. In this case, four-layered microgyria is present bilaterally in middle cerebral artery distribution, but in one hemisphere, in the center of the malformed area, the deep acellular and cellular layers are replaced by radially aligned neurons extending ectopically into prospective white matter. Analysis of the findings in this case provide evidence that the recently described pathogenetic mechanism observed in a rat model of this malformation [15,16] is applicable to its formation in man.

Citing Articles

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Circuit Mechanisms Underlying Epileptogenesis in a Mouse Model of Focal Cortical Malformation.

Yang W, Williams A, Sun Q Curr Biol. 2020; 31(2):334-345.e4.

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Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria.

Paldino M, Hedges K, Gaab N, Galaburda A, Grant P Behav Neurol. 2015; 2015:351391.

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Excitatory and inhibitory synaptic connectivity to layer V fast-spiking interneurons in the freeze lesion model of cortical microgyria.

Jin X, Jiang K, Prince D J Neurophysiol. 2014; 112(7):1703-13.

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Homozygous truncating mutation of the KBP gene, encoding a KIF1B-binding protein, in a familial case of fetal polymicrogyria.

Valence S, Poirier K, Lebrun N, Saillour Y, Sonigo P, Bessieres B Neurogenetics. 2013; 14(3-4):215-24.

PMID: 24072599 DOI: 10.1007/s10048-013-0373-x.

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