The Effect of Leukotriene C4 and D4 on Cutaneous Blood Flow in Humans

Overview

Journal Prostaglandins

Date 1982 Jun 1

PMID 7122908

Citations 10

Authors

H Bisgaard

J Kristensen

J Sondergaard

Affiliations

Soon will be listed here.

Abstract

Using a laser-Doppler-flowmeter the microvascular response to LTC4 and LTD4 was measured. Intradermal injection of 1 microgram LTC4 and LTD4 caused an increase in the microvascular cutaneous bloodflow. The increase in flow was equal to that caused by histamine in equimolar amounts. Blocking the triple-response did not change the response. The values measured after injection of histamine and leucotrienes were about 10-15 times the values found in undisturbed skin and represents probably a maximally dilated vascular bed. Injection of the leucotrienes caused a slight sensation of pain.

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Human epidermis transforms exogenous leukotriene A4 into peptide leukotrienes: possible role in transcellular metabolism.

Iversen L, Kristensen P, Gron B, ZIBOH V, Kragballe K Arch Dermatol Res. 1994; 286(5):261-6.

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Responses of human skin to intradermal injection of leukotrienes C4, D4 and B4.

Camp R, Coutts A, Greaves M, Kay A, Walport M Br J Pharmacol. 1983; 80(3):497-502.

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