Localization of Monoamine Oxidases A and B in Primate Brains Relative to Neuron-specific and Non-neuronal Enolases

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1982 Jun 1

PMID 7121716

Citations 6

Authors

I C Campbell

P J Marangos

A Parma

N A Garrick

D L Murphy

Affiliations

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Abstract

Using serotonin and phenylethylamine deamination as measures of MAO A and MAO B activity respectively, positive correlations were observed between the activities of MAO A and MAO B in different areas of rhesus monkey and human brains. When the activities of MAO A and MAO B were compared with those of neuron-specific enolase and nonneuronal enolase (isozymes which are markers for neurons and glia), a slight but non-significant correlation was observed, suggesting that a simple distribution of MAO A in neurons and MAO B in glia is unlikely. This conclusion is supported by studies using synaptosomes, but contrasts with that from investigations of MAO from peripheral tissues, where experiments indicate that MAO A is predominantly localized in neurones.

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