Regeneration of Ganglion Cell Axons in the Adult Mouse Retina

Overview

Journal Brain Res

Specialty Neurology

Date 1982 Jun 10

PMID 7104718

Citations 7

Authors

P McConnell

M Berry

Affiliations

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Abstract

The hypothesis that regenerative failure of axons in the adult mammalian CNS is due to release of a growth inhibitor from injured oligodendrocytes and/or myelin2, predicts that regeneration of injured fibers would proceed unchecked in unmyelinated CNS regions. This prediction was borne out by observations on the stratum opticarum of the mouse retina. Axonal sprouts, first seen 14-16 h post-lesion (pl), continued growing until at least 100 days pl, well beyond the time at which regeneration fails in myelinated CNS regions.

Citing Articles

Bcl-2 overexpression does not enhance in vivo axonal regeneration of retinal ganglion cells after peripheral nerve transplantation in adult mice.

Inoue T, Hosokawa M, Morigiwa K, Ohashi Y, Fukuda Y J Neurosci. 2002; 22(11):4468-77.

PMID: 12040054 PMC: 6758825. DOI: 20026441.

Regeneration and transplantation of the optic nerve: developing a clinical strategy.

MacLaren R Br J Ophthalmol. 1998; 82(5):577-83.

PMID: 9713068 PMC: 1722609. DOI: 10.1136/bjo.82.5.577.

Brain-derived neurotrophic factor and neurotrophin-4/5 stimulate growth of axonal branches from regenerating retinal ganglion cells.

Sawai H, Clarke D, Kittlerova P, Bray G, Aguayo A J Neurosci. 1996; 16(12):3887-94.

PMID: 8656282 PMC: 6578616.

Regenerative and other responses to injury in the retinal stump of the optic nerve in adult albino rats: transection of the intraorbital optic nerve.

Zeng B, Anderson P, Campbell G, Lieberman A J Anat. 1994; 185 ( Pt 3):643-61.

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Axonal and vascular changes following injury to the rat's optic nerve.

Kiernan J J Anat. 1985; 141:139-54.

PMID: 4077712 PMC: 1166396.