Synthesis of N7-hydroxyethylguanine and O6-hydroxyethylguanine. Markers for the Reaction of Ethylene Oxide (EO) with DNA

Overview

Journal Mutat Res

Publisher Elsevier

Specialty Genetics

Date 1982 Mar 1

PMID 7087988

Citations 4

Authors

J Ashby

D Paton

J A Styles

D Greatbanks

B Wright

Affiliations

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Abstract

O6-Hydroxyethylguanine has been synthesized by reaction of mono-sodium glycolate with 6-chloroguanine. The crystalline product has been characterized using a variety of analytical techniques and compared with a sample of the corresponding N7-hydroxyethyl derivative. These 2 chemicals may prove useful as standards when studying the reaction of ethylene oxide (EO) with DNA.

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