Cerebrospinal Fluid GABA Levels in Various Neurological and Psychiatric Diseases
Overview
Neurosurgery
Psychiatry
Affiliations
Cerebrospinal fluid gamma-aminobutyric acid (CSF-GABA) was analysed by radioreceptor assay in 16 normal controls and 84 patients with various neurological and psychiatric diseases. In patients with spinocerebellar degeneration, neuro-Behçet's syndrome and Parkinson's disease, CSF-GABA levels were decreased. On the other hand, increased CSF-GABA levels were detected in patients with meningitis.
Neuro-Behçet's disease: an update of clinical diagnosis, biomarkers, and immunopathogenesis.
Zhan H, Cheng L, Li Y Clin Exp Immunol. 2025; 219(1).
PMID: 39774671 PMC: 11755846. DOI: 10.1093/cei/uxae123.
Derivation of a metabolic signature associated with bacterial meningitis in infants.
Gordon S, Srinivasan L, Taylor D, Master S, Tremoglie M, Hankeova A Pediatr Res. 2020; 88(2):184-191.
PMID: 32120377 PMC: 7390682. DOI: 10.1038/s41390-020-0816-7.
Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder.
Ogawa S, Hattori K, Sasayama D, Yokota Y, Matsumura R, Matsuo J Sci Rep. 2015; 5:7796.
PMID: 25589364 PMC: 4295090. DOI: 10.1038/srep07796.
Jimenez-Jimenez F, Alonso-Navarro H, Garcia-Martin E, Agundez J Front Cell Neurosci. 2014; 8:369.
PMID: 25426023 PMC: 4227512. DOI: 10.3389/fncel.2014.00369.
Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain.
Berg D, Belnoue L, Song H, Simon A Development. 2013; 140(12):2548-61.
PMID: 23715548 PMC: 3666382. DOI: 10.1242/dev.088005.