Effect of Truncal Vagotomy on Functional and Morphological Changes Produced by Duodenogastric Reflux

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 1982 Jul 1

PMID 7083998

Citations 1

Authors

W E THOMAS

Affiliations

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Abstract

The effects of truncal vagotomy on the functional and morphological changes produced by duodenogastric reflux have been studied in the dog. Duodenogastric reflux caused progressive damage to gastric mucosa, hypersecretion of acid to pentagastrin, and a hypergastrinemic response to a standard meal. Truncal vagotomy barely altered the mucosal changes produced by reflux, but it did prevent antral gland hyperplasia and reduced the acid and gastrin secretory responses. These findings are clinically reassuring in that vagotomy effectively prevented the hypersecretory state produced by duodenogastric reflux.

Citing Articles

Suppression of somatostatin release by duodenogastric reflux in dogs.

THOMAS W, Ardill J, Buchanan K Gut. 1984; 25(11):1230-3.

PMID: 6149979 PMC: 1432327. DOI: 10.1136/gut.25.11.1230.

References

UVNAS B, EMAS S, Fyro B, Sjodin L . The interaction between vagal impulses and gastrin in the control of gastric acid secretion. Am J Dig Dis. 1966; 11(2):103-12. DOI: 10.1007/BF02239235. View

PEVSNER L, GROSSMAN M . The mechanism of vagal stimulation of gastric acid secretion. Gastroenterology. 1955; 28(4):493-9. View

EMAS S, GROSSMAN M . Effect of truncal vagotomy on acid and pepsin responses to histamine and gastrin in dogs. Am J Physiol. 1967; 212(5):1007-12. DOI: 10.1152/ajplegacy.1967.212.5.1007. View

Hoare A, Jones E, Alexander-Williams J, HAWKINS C . Symptomatic significance of gastric mucosal changes after surgery for peptic ulcer. Gut. 1977; 18(4):295-300. PMC: 1411451. DOI: 10.1136/gut.18.4.295. View

Jones T, DEVITO R, Nyhus L, HARKINS H . A prime physiologic mechanism responsible for the failure of gastrojejunostomy in the treatment of peptic ulcer disease. Surgery. 1958; 43(5):781-6. View

Flint F, Grech P . Pyloric regurgitation and gastric ulcer. Gut. 1970; 11(9):735-7. PMC: 1553111. DOI: 10.1136/gut.11.9.735. View

OLBE L . EFFECT OF RESECTION OF GASTRIN RELEASING REGIONS ON ACID RESPONSE TO SHAM FEEDING AND INSULIN HYPOGLYCEMIA IN PAVLOV POUCH DOGS. Acta Physiol Scand. 1964; 62:169-75. DOI: 10.1111/j.1748-1716.1964.tb03965.x. View

Tepperman B, Walsh J, Preshaw R . Effect of antral denervation on gastrin release by sham feeding and insulin hypoglycemia in dogs. Gastroenterology. 1972; 63(6):973-80. View

THOMAS W . Functional changes in acid secretion produced by duodenogastric reflux. Gut. 1980; 21(5):413-7. PMC: 1419095. DOI: 10.1136/gut.21.5.413. View

10.

Thein M, Schofield B . Release of gastrin from the pyloric antrum following vagal stimulation by sham feeding in dogs. J Physiol. 1959; 148(2):291-305. PMC: 1363074. DOI: 10.1113/jphysiol.1959.sp006289. View

11.

PASSARO Jr E, GROSSMAN M . EFFECT OF VAGAL INNERVATION ON ACID AND PEPSIN RESPONSE TO HISTAMINE AND GASTRIN. Am J Physiol. 1964; 206:1068-76. DOI: 10.1152/ajplegacy.1964.206.5.1068. View

12.

Yalow R, Berson S . Radioimmunoassay of gastrin. Gastroenterology. 1970; 58(1):1-14. View

13.

Schmitz E, KANAR E, STORER E, Sauvage L, HARKINS H . Heidenhain pouch secretory response as affected by gastrojejunostomy to the main stomach. Proc Soc Exp Biol Med. 1952; 81(1):170-2. DOI: 10.3181/00379727-81-19813. View

14.

NAHRWOLD D . Bile as a gastric secretory stimulant. Surgery. 1972; 71(2):157-60. View

15.

Russell R, Hobsley M . Pyloric reflux in duodenal ulceration and its relationship to smoking. Br J Surg. 1973; 60(4):321. View