Autoimmune Thyroiditis: Conversion of Low-responder Mice to High-responders by Cyclophosphamide

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1982 Mar 1

PMID 7083636

Citations 4

Authors

A O Vladutiu

Affiliations

Soon will be listed here.

Abstract

Inbred strains of mice are low- or high-responders with respect to the magnitude of thyroid infiltrates that appear after immunization with mouse thyroglobulin emulsified in Freund's complete adjuvant. This aspect of the immune response to thyroglobulin is strongly controlled by the major histocompatibility complex. Low-responder strains treated with cyclophosphamide, before the antigenic challenge, were converted to high-responders. This suggests that in low-responder mice, a specific suppressor activity influences the development of the thyroid lesions characteristic for the autoimmune thyroiditis.

Citing Articles

Characterization of a thyroiditis-inducing thyroglobulin-specific T-cell clone restricted by the H-2 molecule of a low responder mouse strain.

Hiyama Y, Kohno Y, Hoshioka A, Shimojo N, TARUTANI O, Yokochi T Immunology. 1993; 80(3):488-92.

PMID: 8288321 PMC: 1422206.

Experimental autoimmune thyroiditis: modulation of the disease level in high and low responder mice by thymosin.

Tomazic V, Suter C, Chretien P Clin Exp Immunol. 1984; 58(1):83-9.

PMID: 6478652 PMC: 1576955.

Genetic susceptibility to murine collagen II autoimmune arthritis. Proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non-MHC loci.

Watson W, Townes A J Exp Med. 1985; 162(6):1878-91.

PMID: 3934318 PMC: 2187982. DOI: 10.1084/jem.162.6.1878.

Occurrence of lymphocyte proliferative response to thyroglobulin and antithyroglobulin antibodies in normal individuals: lack of correlation with HLA.

Bagnasco M, Orlandini A, Melioli G, Venuti D, Canonica G, Ferrara G J Endocrinol Invest. 1987; 10(2):203-6.

PMID: 3584860 DOI: 10.1007/BF03347192.

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