Induction of Bladder Cancer in Rats by Fractionated Intravesicular Doses of N-methyl-N-nitrosourea

Overview

Journal Br J Cancer

Specialty Oncology

Date 1982 Mar 1

PMID 7073931

Citations 6

Authors

N J Severs

S H Barnes

R Wright

R M Hicks

Affiliations

Soon will be listed here.

Abstract

Experiments were conducted to determine the dose response of rat bladder urothelium to a range of different single and fractionated intravesicular doses of the carcinogen, N-methyl-N-nitrosourea (MNU). A dose-related response of bladder-tumour incidence to single graded doses of MNU was found, and a threshold does suitable for use of multistage carcinogenesis experiments was derived from these data. For any given total dose of MNU, the tumour incidence was greater if the MNU had been administered in several small fractions than if it had been administered in fewer larger ones. Extending the interval between doses did not reduce the tumour incidence. It is argued that these results support the multistage theory of carcinogenesis. The histopathology and cell-surface alterations which characterize the development of MNU-induced bladder cancer are described and the contribution of hyperplasia and calculi are discussed.

Citing Articles

Bracken fern-induced bladder tumors in guinea pigs. A model for human neoplasia.

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The induction of urothelial hyperplasia by methyl methanesulphonate and ethyl methanesulphonate.

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Effect of promoters on incidence of bladder cancer in experimental animal models.

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Modification of N-methyl-N-nitrosourea-induced urinary bladder carcinogenesis in rats following stimulation of urothelial proliferation by a partial cystectomy.

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